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http://www.iptonline.com/articles/public/IPT_17_2005_p74_76.pdf
The Buccal Delivery of Insulin A system for the administration of medicines directly into the mouth for absorption by the buccal mucosa is showing promise in the oral delivery of insulin – as well as other large-molecule drugs. By Gerald Bernstein at Generex Biotechnology Corporation
https://www.sciencedirect.com/topics/medicine-and-dentistry/buccal-drug-administration
However, due to the effects of the constant flow of saliva and the relatively thick, multilayered buccal barrier, the buccal and sublingual mucosa presents problems for insulin delivery [12]. A drug delivered through the buccal route enters directly into the systemic circulation, bypassing the hepatic first-pass metabolism.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769877/
In this study, buccal insulin will be compared to prandial injections of regular insulin (not rapid-acting insulin analogs); using twice-daily NPH as basal insulin. So the comparator is a more classical insulin therapy.Author: Lutz Heinemann, Yves Jacques
https://www.researchgate.net/publication/23221165_Delivery_of_insulin_to_the_buccal_mucosa_utilizing_the_RapidMist_system
The RapidMist drug delivery system places human recombinant insulin in a liquid formulation so as to be delivered to the buccal mucosa with an asthma-like device.Author: Gerald Bernstein
https://journals.sagepub.com/doi/pdf/10.1177/193229680900300323
injections is the use of microneedles for insulin delivery. With intradermal injection or infusion of regular human insulin or a rapid-acting insulin analog, a rapid onset of action along with a meal can be achieved.2 The aim of this review is to critically review our current knowledge about oral insulin and buccal insulin, two other quite
https://link.springer.com/article/10.1007%2Fs11095-014-1485-1
Aug 29, 2014 · However, the buccal mucosa still exhibits some permeability-limiting properties, and therefore various methods have been explored to enhance the delivery of macromolecules via this route, including the use of chemical penetration enhancers, physical methods,...Author: Thiago Caon, Thiago Caon, Liang Jin, M O Claudia Simoes, Raymond Stanley Norton, Joseph Nicolazzo
https://sites.ualberta.ca/~csps/JPPS1(1)/A.Shojaei/buccalreview.htm
Within the oral mucosal cavity, delivery of drugs is classified into three categories: (i) sublingual delivery, which is systemic delivery of drugs through the mucosal membranes lining the floor of the mouth, (ii) buccal delivery, which is drug administration through the mucosal …
https://www.researchgate.net/profile/Garima_Goomber/publication/228488357_Emerging_trends_in_insulin_delivery_Buccal_route/links/53dd07e60cf2a76fb667c5a3.pdf
buccal mucosa has emerged as a promising delivery site for insulin. Buccal mucosa offers a rich vasculature, relatively immobile mucosa and an expanse of smooth muscle. Structure of
https://www.intechopen.com/books/application-of-nanotechnology-in-drug-delivery/nanoparticle-insulin-drug-delivery-applications-and-new-aspects
Pulmonary administration is one of the most promising alternative route of insulin delivery. The lungs offer a large and highly vascularised surface area for drug …Author: Hatice Kübra Elçioğlu, Ali Demir Sezer
http://ijpsr.com/bft-article/a-detailed-review-on-oral-mucosal-drug-delivery-system/?view=fulltext
Buccal delivery for insulin has been investigated using different formulations such as buccoadhesive tablets, deformable vesicles, and pelleted bioadhesive polymeric nanoparticles. Generex Biotechnology (Toronto, Ontario, Canada) markets a spray for delivery of insulin through the buccal mucosa.
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