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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232272/
Aug 28, 2013 · Breath Powered delivery of sumatriptan powder with the OptiNose device avoids many of the delivery inadequacies of a typical spray by distributing powder to the area beyond the nasal valve, producing an absorption profile consistent with proportionately more intranasal and less GI absorption.Author: Mohammad Obaidi, Elliot Offman, John Messina, Jennifer Carothers, Per G. Djupesland, Ramy A. Mahmoud
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786533/
This barrier, plus the inherent limitations of traditional nasal delivery mechanisms, has precluded achievement of the full potential of nasal delivery. Breath Powered bi-directional delivery, a simple but novel nasal delivery mechanism, overcomes these barriers. This innovative mechanism has now been applied to the delivery of sumatriptan.Author: Per G. Djupesland, John C. Messina, Ramy A. Mahmoud
http://www.multivu.com/players/English/57713-optinose-innovative-breath-powered-nasal-delivery-technology-delivers-drugs-to-treat-variety-of-medical-conditions/
Comprehensive clinical program is designed to support registration of OPN-375 (Fluticasone delivered with OptiNose’s Novel Breath Powered™ intranasal delivery device) in the United States and build on company’s mission to transform the static nasal drug delivery market
https://headachejournal.onlinelibrary.wiley.com/doi/full/10.1111/head.12186
This barrier, plus the inherent limitations of traditional nasal delivery mechanisms, has precluded achievement of the full potential of nasal delivery. Breath Powered bi‐directional delivery, a simple but novel nasal delivery mechanism, overcomes these barriers. This innovative mechanism has now been applied to the delivery of sumatriptan.Author: Per G. Djupesland, John C. Messina, Ramy A. Mahmoud
https://www.researchgate.net/publication/256663209_Breath_Powered_Nasal_Delivery_A_New_Route_to_Rapid_Headache_Relief
Breath Powered bi-directional delivery, a simple but novel nasal delivery mechanism, overcomes these barriers. This innovative mechanism has now been applied to the delivery of sumatriptan.
https://americanmigrainefoundation.org/resource-library/breath-powered-intranasal-sumatriptan-dry-powder/
A breath-powered delivery system for sumatriptan dry powder (brand name Onzetra Xsail, Alisa Viejo, CA, USA) is approved by the Food and Drug Administration (FDA) for the treatment of migraine attacks. Sumatriptan is the oldest of the triptan family. Available in the United States in tablet, liquid nasal, injectable, and skin patch forms.
https://onlinelibrary.wiley.com/doi/full/10.1111/head.12472
Oct 30, 2014 · Stephen D. Silberstein, A review of clinical safety data for sumatriptan nasal powder administered by a breath powered exhalation delivery system in the acute treatment of migraine, Expert Opinion on Drug Safety, 10.1080/14740338.2018.1390563, 17, 1, (89-97), (2017).Author: Roger K. Cady, Peter J. McAllister, Egilius L.H. Spierings, John Messina, Jennifer Carothers, Per G....
https://www.optinose.com/exhalation-delivery-systems/technical-overview
Exhalation Delivery Systems. The innovative mechanism of action of the first Optinose technology is designed to enable broad, consistent drug delivery high and deep in the nasal passages, leveraging the mucosal surfaces as a potential target for the treatment of both local and systemic diseases.
https://www.optinose.com/wp-content/uploads/2015/03/Cady-Headache-2015.pdf
Key words: migraine, Bi-Directional nasal delivery, Breath Powered nasal delivery, intranasal delivery, sumatriptan powder, AVP-825 Abbreviations: AE adverse event, AVP-825 Breath Powered delivery of low-dose sumatriptan powder, CGRP calcitonin gene-related peptide, CO 2 carbon dioxide, ECG electrocardiogram, e-diary electronic diary, FAS full ...
http://www.multivu.com/players/English/57713-optinose-innovative-breath-powered-nasal-delivery-technology-delivers-drugs-to-treat-variety-of-medical-conditions/flexSwf/impAsset/document/5f82bfc7-f568-4eb0-af11-651460c748fc.pdf
OptiNose is a drug delivery company developing a breakthrough Breath Powered™ nasal technology set to transform the static nasal drug delivery market. OptiNose devices are designed to reliably deliver nasal medication to target regions of the nasal cavity, including the …
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