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https://www.researchgate.net/publication/279408805_Brain_targeting_Drug_Delivery_System_A_Review
The most distressing fact about delivery of drugs to the CNS is the presence of blood brain barrier that have a tendency to impair the drug distribution and denotes the major impediment for the development of CNS drugs. Neuropeptides and many drugs which are hydrophilic in nature,...
https://www.elsevier.com/books/brain-targeted-drug-delivery-systems/gao/978-0-12-814001-7
Brain Targeted Drug Delivery Systems: A Focus on Nanotechnology and Nanoparticulates provides a guide on nanoparticulates to both academic and industry researchers. The book discusses key points in the development of brain targeted drug delivery, summarizes available strategies, and considers the main problems and pitfalls evidenced in current studies on brain targeted drug delivery systems.
https://www.mdpi.com/1999-4923/11/2/84/pdf
The easiest classification of NEs designed for nose-to-brain delivery is based on the drug loaded and the therapeutic purpose. As the final target is the brain through the nose, the pharmacological actions regard pathologies of the CNS. In one case, a probe is loaded in the NE to obtain brain imaging.Author: Maria Cristina Bonferoni, Silvia Rossi, Giuseppina Sandri, Franca Ferrari, Elisabetta Gavini, Giovan...
http://www.thno.org/v08p1481.pdf
The blood-brain barrier (BBB) has been a great hurdle for brain drug delivery. The BBB in healthy brain is a diffusion barrier essential for protecting normal brain function by impeding most compounds from transiting from the blood to the brain; only small molecules can cross the BBB.
http://isca.in/rjcs/Archives/v1/i2/20.pdf
Brain targeted drug delivery system: The brain is a delicate organ, and evolution built very efficient ways to protect it. The delivery of drugs to central nervous system (CNS) is a challenge in the treatment of neurological disorders. Drugs may be administered directly into the CNS or administeredFile Size: 474KB
https://www.slideshare.net/VARSHAAWASAR/brain-targeted-drug-delivery-system
Aug 04, 2014 · PS Mohanachandran, PG Sindhumol, “Recent trends in brain targeting drug delivery system: An overview”, International Journal of Comprehensive Pharmacy, volume 3, issue 10, page no. 1-9. 3. Drug delivery to the brain, From Wikipedia, the free encyclopedia.
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