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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184840/
Oct 03, 2014 · Among these strategies, intranasal (IN) delivery is a non-invasive approach for direct drug delivery to the brain via the nose, bypassing the BBB . IN administration has emerged as a promising approach for drug delivery to the brain.Author: Hong Chen, Cherry C. Chen, Camilo Acosta, Shih-Ying Wu, Tao Sun, Elisa E. Konofagou
http://www.thno.org/v08p1481.htm
Thus, the combination of the BBB and the BBTB form a major barrier for brain tumor drug delivery. Strategies that are applied to overcome the BBB, including opening TJs by a hyperosmotic solution of mannitol or a compound (e.g., bradykinin), inhibiting efflux drug transporters, and receptor-mediated drug delivery systems, may also be exploited to selectively enhance drug delivery to brain tumors.Author: Xiaowei Dong
http://www.thno.org/v08p1481.pdf
a major barrier for brain tumor drug delivery. Strategies that are applied to overcome the BBB, including opening TJs by a hyperosmotic solution of mannitol or a compound (e.g., bradykinin), inhibiting efflux drug transporters, and receptormediated drug - delivery systems, may also be exploited to selectively enhance drug delivery to brain tumors.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629063/
Apr 05, 2014 · Brain tumor-targeted drug delivery systems, which increase drug accumulation in the tumor region and reduce toxicity in normal brain and peripheral tissue, are a promising new approach to brain tumor treatments.Author: Xiaoli Wei, Xishan Chen, Man Ying, Weiyue Lu
https://www.sciencedirect.com/science/article/pii/B9780323429788000048
Conventional Strategies for Brain Drug Delivery Drug delivery to the CNS is highly challenging. Various drug delivery strategies have been employed to improve patient compliance, prolong drug half-life, minimize healthcare costs, and improve pharmacokinetics of degradable peptides and proteins.Author: Abhirup Mandal, Rohit Bisht, Dhananjay Pal, Ashim K. Mitra
https://www.sciencedirect.com/science/article/pii/S0928098710001818
The conventional drug delivery systems which release drug into general circulation fail to deliver drugs effectively to brain and is therefore not very useful in treating certain diseases that affect CNS including Alzheimer's disease, dementia, Parkinson's disease, mood disorder, AIDS, viral and bacterial meningitis.Author: M. Intakhab Alam, Sarwar Beg, Abdus Samad, Sanjula Baboota, Kanchan Kohli, Javed Ali, Alka Ahuja, M....
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900538/
Strategies for delivery of therapeutics across the blood-brain barrier include osmotic/chemical disruption, enhanced transcytosis (e.g. receptor-mediated mechanisms), nanoparticles/nanotubes, cell-mediated delivery, and ultrasound-mediated BBB opening. Interstitial wafers/microchips and catheter-enhanced local delivery bypass the barrier entirely.Author: David S. Hersh, Aniket S. Wadajkar, Nathan B. Roberts, Jimena G. Perez, Nina P. Connolly, Victor Fre...
https://www.sciencedirect.com/science/article/pii/S2211383514000288
Brain tumor-targeted drug delivery systems, which increase drug accumulation in the tumor region and reduce toxicity in normal brain and peripheral tissue, are a promising new approach to brain tumor treatments.Author: Xiaoli Wei, Xishan Chen, Man Ying, Weiyue Lu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752842/
Intracerebral implantation of chemotherapeutic agents containing polymeric matrix or reservoir is another highly invasive drug delivery strategy, which is well established and commercially available. Characteristics of these implants, including rate-controlling mechanisms, degree of biodegradability, shapes and sizes, differ.Author: Valentino Laquintana, Adriana Trapani, Nunzio Denora, Fan Wang, James M Gallo, Giuseppe Trapani
https://www.researchgate.net/publication/279408805_Brain_targeting_Drug_Delivery_System_A_Review
In order to distribute the drugs into the CNS via passing the blood brain barrier, many new emerging approaches have been developed for example Magnetic drug targeting, chemical delivery Systems ...
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