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https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201914751
Jan 29, 2020 · Systemic Brain Delivery of Antisense Oligonucleotides across the Blood–Brain Barrier with a Glucose‐Coated Polymeric Nanocarrier. Dr. Hyun Su Min. Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, …Author: Hyun Su Min, Hyun Jin Kim, Mitsuru Naito, Satomi Ogura, Kazuko Toh, Kotaro Hayashi, Beob Soo Kim, Sh...
http://jpet.aspetjournals.org/content/370/3/593
Sep 01, 2019 · Nose-to-Brain Mechanism of Delivery. For the purposes of drug delivery, the nasal cavity is divided into the respiratory area and the olfactory area, with the latter situated high up in the nares and the former closer to the nostrils (Sahin-Yilmaz and Naclerio, 2011).The nasal epithelium is well vascularized (Sahin-Yilmaz and Naclerio, 2011), and, within the olfactory area, olfactory neurons ...Author: Zian Wang, Guojun Xiong, Wai Chun Tsang, Andreas G. Schätzlein, Ijeoma F. Uchegbu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161189/
Aug 03, 2018 · Alternative drug delivery routes like intraparenchymal or intrathecal are invasive methods with a remaining risk of infections. In contrast, nose-to-brain delivery is a minimally invasive drug administration pathway, which bypasses the blood-brain barrier as the drug is directed from the nasal cavity to the brain.Author: Stella Gänger, Katharina Schindowski
https://www.ncbi.nlm.nih.gov/pubmed/31837821
Dec 06, 2019 · Direct nose-to-brain (N-to-B) delivery enables the rapid transport of drugs to the brain, while minimizing systemic exposure. The objective of this work was to engineer a nanocarrier intended to enhance N-to-B delivery of RNA and to explore its potential utility for …Author: Eleni Samaridou, Hannah Walgrave, Evgenia Salta, David Moreira Álvarez, Vanessa Castro-López, Mabel ...
https://onlinelibrary.wiley.com/doi/full/10.1002/advs.201700897
Brain Delivery of Multifunctional Dendrimer Protein Bioconjugates. Pierpaolo Moscariello. Institute of Physiology, University Medical Center of Johannes Gutenberg University Mainz, Duesbergweg 6, D‐55128 Mainz, Germany. Present address: Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany.Author: Pierpaolo Moscariello, David Y. W. Ng, Malin Jansen, Tanja Weil, Heiko J. Luhmann, Jana Hedrich
http://mysticpharmaceuticals.com/nose-to-brain-delivery/
Mystic offers patient-centric delivery systems for systemic intranasal, nose-to-brain, ophthalmic, sublingual, dermal and oral delivery. Our delivery platforms and integration services provides a custom optimized delivery system in combination with your drug or biologic to meet your technical product and market requirements.
https://www.mdpi.com/journal/pharmaceutics/special_issues/nose_brain_delivery
Nose-to-brain delivery represents a big challenge. In fact there is a large number of neurological diseases that require therapies in which the drug must reach the brain, avoiding the difficulties due to the blood–brain barrier (BBB) and the problems connected with systemic administration, such as drug bioavailability and side-effects.
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