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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751454/
Feb 05, 2008 · PRODRUG CONCEPT. The term “prodrug” or “pro-agent” was first introduced in 1958 to describe compounds that undergo biotransformation prior to their therapeutic activity ().Prodrugs are described as bioreversible derivatives of drug molecules that must undergo a chemical or enzymatic biotransformation to the active forms within the body, prior to exerting a pharmacological action (Fig. 2).Author: Jarkko Rautio, Krista Laine, Mikko Gynther, Jouko Savolainen
https://pdfs.semanticscholar.org/5d0b/992e3ec51f80999e1d8626a362da8e232e05.pdf
enhanced drug permeability through blood brain barrier. 3.The nanoformulations may be endocytosed by the endothelial cells of the brain capillaries which would further result in the release of the drugs within these cells and delivery to the brain. 4.Drug loaded nanoformulations could be transcytosed through the endothelial cell layer.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407659/
The purpose of this review is to provide an update on the utilization of prodrug concept in ocular drug delivery. In addition, this review will highlight ongoing academic and industrial research and development in terms of ocular prodrug design and delivery.Author: Megha Barot, Mahuya Bagui, Mitan R. Gokulgandhi, Ashim K. Mitra
https://pdfs.semanticscholar.org/2f7b/c003a6f7e9d9a66ba66e10bc5f3c13a69d7b.pdf
type redox system was developed for brain specific sustained delivery of drug. The drug containing amine group is made lipophilic by coupling to dihydropyridine promoiety that facilitate penetration of prodrug through the blood brain barrier. In the CNS dihydropridine group …
https://sites.ualberta.ca/~csps/JPPS6(2)/A.Misra/delivery.pdf
Drug delivery to the central nervous system: a review. Ambikanandan Misra, Ganesh S., Aliasgar Shahiwala Pharmacy Department, M.S. University of Baroda Shrenik P. Shah Sun Pharma Advanced Research Center, Baroda Received 16 June 2003, Revised 26 June 2003, Accepted 5 August 2003 Abstract The brain is a delicate organ, and evolution built
https://www.mdpi.com/1999-4923/11/7/349/htm
Using thyrotropin-releasing hormone (TRH) as a model, we explored whether synergistic combination of lipoamino acid(s) and a linker cleaved by prolyl oligopeptidase (POP) can be used as a promoiety for prodrug design for the preferential brain delivery of the peptide. A representative prodrug based on this design principle was synthesized, and its membrane affinity and in vitro metabolic ...Author: Katalin Prokai-Tatrai, Daniel L. De La Cruz, Vien Nguyen, Benjamin P. Ross, Istvan Toth, Laszlo Prok...
https://www.researchgate.net/publication/5404956_Prodrug_Approaches_for_CNS_Delivery
PRODRUG CONCEPT. The term ... through increased brain e ntry (32, 33). For example, chloram- ... 95 Prodrug Approaches for CNS Delivery. ENDOGENOUS …
http://www.authorstream.com/Presentation/amol.sabale-1380346-brain-targeted-drug-delivery-system/
Apr 05, 2012 · INTRODUCTION:: INTRODUCTION : Delivery of drug to CNS is challenge in treatment of CNS disorder Many conventional drug delivery system are ineffective Pharmacological response of drug is dependent on the distribution of the drug to the target tissue The impact of the blood-brain barrier (BBB) in CNS drug therapy is major concerned There are many obstacles in drug delivery to the brain …
https://www.mdpi.com/1420-3049/24/22/4197/htm
The best-known concept that relies on an oxidative lock-in mechanism for enhanced brain delivery is the prodrug concept termed chemical delivery system (CDS) that utilizes dihydropyridine-based promoieties [45,46]. These can easily be oxidized to the corresponding pyridiniums on the analogy of NAD(P)H ↔ NAD(P) +. Mostly ester- and carbamate ...Author: Katalin Prokai-Tatrai, Laszlo Prokai
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