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https://www.sciencedirect.com/science/article/pii/S0142961217307640
For bone marrow drug delivery, the drug accumulation amounts in the bone are ascribed to the uptake of particulates by phagocytic reticulo-endothelial cells of sinusoid vessels in the bone marrow . The endothelium of vascular sinusoids collects particulates from the blood circulation via both transcellular and intercellular routes.Author: Chao-Feng Mu, Jianliang Shen, Jianliang Shen, Jing Liang, Hang-Sheng Zheng, Yang Xiong, Ying-Hui Wei...
https://pharm.ucsf.edu/desai/research/osteomyelitis
Bone drug delivery. Osteomyelitis is a bone or bone marrow infection that requires prolonged antibiotic therapy and surgical debridement. We are developing nanoparticles that both release a therapeutic payload and restructure damaged bone.
https://www.ncbi.nlm.nih.gov/pubmed/29471078
To date, therapeutic approaches for bone regeneration rely heavily on protein-based growth factors such as INFUSE, an FDA-approved scaffold for delivery of bone morphogenetic protein 2 (BMP-2). Small molecule modulators and RNAi therapeutics are under development to circumvent challenges associated with traditional growth factors.Author: Yuchen Wang, Yuchen Wang, Maureen R. Newman, Maureen R. Newman, Danielle S.W. Benoit
https://www.ncbi.nlm.nih.gov/pubmed/27064433/
Local and targeted drug delivery for bone regeneration. Newman MR(1), Benoit DS(2). Author information: (1)Department of Biomedical Engineering, University of Rochester, Rochester, NY, USA; Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA.Author: Maureen R Newman, Maureen R Newman, Danielle Sw Benoit, Danielle Sw Benoit
https://link.springer.com/article/10.2165/00003088-200342150-00002
Sep 13, 2012 · Despite several decades of progress, bone-specific delivery is still limited by the unique anatomical features of bone, which mainly consists of inorganic hydroxyapatite. A practical approach to this problem is to produce targeted drugs that have a high affinity for hydroxyapatite. Bisphosphonates are a class of synthetic compounds structurally related to pyrophosphate. Bisphosphonates rapidly ...Author: Hideki Hirabayashi, Jiro Fujisaki
https://www.sciencedirect.com/science/article/pii/S1359644617302404
The most representative nanomaterials for bone drug delivery are summarized. • Nanomaterials can target bone by oral, implant, injectable, and transdermal route. • Nanodelivery systems can target bone cells and subcellular organelles. • Outlooks and hurdles …Author: Hao Cheng, Hao Cheng, Hao Cheng, Aditya Chawla, Aditya Chawla, Aditya Chawla, Yafeng Yang, Yafeng Ya...
https://en.wikipedia.org/wiki/Intraosseous_infusion
Intraosseous infusion (IO) is the process of injecting directly into the marrow of a bone. This provides a non-collapsible entry point into the systemic venous system. This technique is used to provide fluids and medication when intravenous access is not available or not feasible. Intraosseous infusions allow for the administered medications and fluids to go directly into the vascular system.
https://journals.sagepub.com/doi/pdf/10.7785/tcrt.2012.500331
Collagen-hydroxyapatite/Cisplatin Drug Delivery Systems for Locoregional Treatment of Bone Cancer www.tcrt.org DOI: 10.7785/tcrt.2012.500331 In this paper, the synthesis and characterization of novel cisplatin-loaded collagen (COLL)/ hydroxyapatite (HA) composite materials are …
https://www.ott.nih.gov/technology/e-165-2012
The National Heart, Lung, and Blood Institute is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize Intra-bone Drug Delivery Device and Method. For collaboration opportunities, please contact Denise Crooks at [email protected]. Licensing Contact:
https://www.nibib.nih.gov/science-education/science-topics/drug-delivery-systems-getting-drugs-their-targets-controlled-manner
Drug delivery systems are engineered technologies for the targeted delivery and/or controlled release of therapeutic agents. Drugs have long been used to improve health and extend lives. The practice of drug delivery has changed dramatically in the past few decades and even greater changes are …
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