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https://www.uclb.com/technologies/drug-delivery-system-for-crossing-the-blood-brain-or-blood-retinal-barrier-udds/
Drug Delivery System for Crossing the Blood Brain or Blood Retinal Barrier (UDDS) Available For: Exclusive licensing Summary. The blood retinal barrier (BRB), and the blood brain barrier (BBB), represent a significant impediment to drug delivery to the eye and the brain, respectively.
https://www.sciencedirect.com/science/article/pii/S1359644618305117
The blood–retinal barrier as a challenge for photoreceptor drug delivery. Review of nanoparticle drug delivery systems used for intraocular applications. Perspectives for topical drug delivery to the retina. The photoreceptors of the retina are afflicted by diseases that still often lack satisfactory treatment options.Author: Erico Himawan, Per Ekström, Matej Buzgo, Pieter Gaillard, Einar Stefánsson, Valeria Marigo, Thorstei...
https://www.sciencedirect.com/science/article/pii/S1350946216300635
In the case of systemic, suprachoroidal and periocular drug administration, the drug must cross the blood-ocular barrier before it can reach the targets in the retina. Therefore, blood-ocular barriers play an important role in defining drug permeation into the eye and from the eye to the blood circulation.Author: Eva M. del Amo, Anna-Kaisa Irmeli Rimpelä, Emma Heikkinen, Otto K. Kari, Eva Ramsay, Tatu Lajunen, M...
The blood-brain barrier and blood-retina barrier limit drug uptake G-Technology® safely enhances brain and eye drug delivery 2-BBB develops medicines for the treatment of brain and eye diseases
https://onlinelibrary.wiley.com/doi/full/10.1002/jps.22610
However, transport of drugs from the circulating blood to the retina is strictly regulated by two blood–ocular barrier systems: the blood–aqueous humor barrier (BAB) and the blood–retinal barrier (BRB). 4,5 These barriers limit the ocular bioavailability of systemically administered drug. Therefore, large systemic doses are required to ...Author: Ryotaro Toda, Kouichi Kawazu, Masanobu Oyabu, Tatsuya Miyazaki, Yoshiaki Kiuchi
https://www.touchophthalmology.com/the-blood-retinal-barrier-in-retinal-disease/
Relevance of the Blood–Retinal Barrier to Treatment of Retinal Diseases When administered systemically, drugs must pass the BRB in order to reach therapeutic levels in the retina. Drug entrance into the retina depends on a number of factors, including the plasma concentration profile of the drug, the volume of its distribution, plasma protein binding and the relative permeability of the BRB.
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