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https://www.springer.com/gp/book/9781461351412
The vasculature of the central nervous system (eNS) is characterized by the existence of the blood-brain barrier (BBB), which can be regarded as both an anatomical and physiological phenomenon. The BBB is formed by a complex cellular system of endothelial cells, astroglia, pericytes, perivascular
https://www.amazon.com/Blood-Brain-Barrier-Delivery-Brain-Pathology-ebook/dp/B000WEG0GM
Blood-Brain Barrier: Drug Delivery and Brain Pathology - Kindle edition by David Kobiler, Shlomo Lustig, Shlomo Shapira. Download it once and read it on your Kindle device, PC, phones or tablets. Use features like bookmarks, note taking and highlighting while reading Blood-Brain Barrier: Drug Delivery and Brain Pathology.5/5(1)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388327/
The presence of the blood-brain barrier (BBB) is a significant impediment to the delivery of therapeutic agents to the brain for treatment of brain diseases. Focused ultrasound (FUS) has been developed as a non-invasive method for transiently increasing the permeability of the BBB to promote drug delivery to targeted regions of the brain.Author: Alison Burgess, Kullervo H. Hynynen
https://www.ncbi.nlm.nih.gov/pubmed/27020469
INTRODUCTION: There are 2 misconceptions about the cerebrospinal fluid (CSF), the blood-brain barrier (BBB), and brain drug delivery, which date back to the discovery of a barrier between blood and brain over 100 years ago. Misconception 1 is that drug distribution into CSF is a …Author: William M. Pardridge
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC539316/
Therefore, the lipidized form of the drug is rapidly removed from the blood, and in pharmacokinetic terms, the plasma area under the concentration curve (AUC) is substantially decreased for the lipidized form of the drug. Drug action in brain is a function of drug uptake…
https://www.ncbi.nlm.nih.gov/pubmed/26453169
1. J Drug Target. 2015;23(7-8):736-49. doi: 10.3109/1061186X.2015.1065833. Systemic delivery of blood-brain barrier-targeted polymeric nanoparticles enhances delivery to brain tissue.Author: Saucier-Sawyer Jk, Deng Y, Seo Ye, Cheng Cj, Zhang J, Quijano E, Saltzman Wm
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