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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1475956/
The incidence of urinary incontinence and overactive bladder problems will continue to grow as the population ages. Future treatments are likely to include an implantable drug delivery system, gene therapy, and the intravesical use of the vallinoids capsaicin and resiniferatoxin (RTX).Author: Matthew O Fraser, John P Lavelle, Michael S Sacks, Michael B Chancellor
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664547/
Nov 23, 2015 · Drug-delivery systems (DDSs) have been introduced to control rate, time, and place of release. Drugs can easily reach the bladder through a catheter, while systemically administered agents may undergo extensive metabolism. Continuous urine filling and subsequent washout hinder intravesical drug delivery (IDD).Author: Martino Maria Zacchè, Sushma Srikrishna, Linda Cardozo
https://www.sciencedirect.com/science/article/pii/S1773224719320258
Drug delivery systems especially being endowed with the targeting property may provide a feasible means to solve such problems. Herein, we have reviewed the recent progress of the drug delivery systems aiming at bladder cancer therapy especially focusing on their targeting strategies.Author: Kun Yu, Meiping Liu, Hong Dai, Xiao Huang
Vensica is leveraging the known properties of ultrasound (increased tissue permeability and improved uptake of drugs) and is developing a drug delivery platform to the urinary bladder. Using the Vensica device, ultrasound cavitation safely and effectively delivers Botulinum Toxin A into the bladder wall in a quick, pain-free, needle-free ...
http://www.sitkabiopharma.com/
IMPROVEMENT OVER CURRENT THERAPIES. Sitka’s technology combines a nanoparticulate drug delivery technology based on hyperbranched polyglycerols (HPG), with docetaxel, a well-characterized chemotherapeutic, in a single proprietary formulation designed for intravesical instillation into the bladder.
http://europepmc.org/articles/PMC4664547
A significant amount of work in drug delivery targeted to the bladder has focused on the disorders mentioned above. Drugs may be either administered directly to the bladder, or given systemically and targeted to the bladder. Most of the drugs available for treatment of …Author: Martino Maria Zacchè, Sushma Srikrishna, Linda Cardozo
https://www.dovepress.com/novel-targeted-bladder-drug-delivery-systems-a-review-peer-reviewed-fulltext-article-RRU
Novel targeted bladder drug-delivery systems: a review Martino Maria Zacchè, Sushma Srikrishna, Linda Cardozo Department of Urogynaecology, King's College Hospital, London, UK Abstract: The objective of pharmaceutics is the development of drugs with increased efficacy and reduced side effects. Prolonged exposure of the diseased tissue to the drug is of crucial importance.
https://www.sbir.gov/sbirsearch/detail/216986
A first patent has already been issued by the USPTO titled Application of Lipid Vehicles and Use for Drug Delivery, patent number 7,063,860, awarded June 20, 2006. This is totally new SBIR-I submission. Lipella will explore the pipeline potential of using intravesical liposome as …
https://www.dovepress.com/novel-targeted-bladder-drug-delivery-systems-a-review-peer-reviewed-article-RRU
Novel targeted bladder drug-delivery systems: a review Martino Maria Zacchè, Sushma Srikrishna, Linda Cardozo Department of Urogynaecology, King's College Hospital, London, UK Abstract: The objective of pharmaceutics is the development of drugs with increased efficacy and reduced side effects. Prolonged exposure of the diseased tissue to the drug is of crucial importance.
https://www.sbir.gov/sbirsearch/detail/370495
Bladder drug delivery using intravesical liposomes to treat overactive bladder. ... Drug delivery to block bladder inflammation will be an objective of this project and the successful completion of this grant will allow Lipella Pharmaceuticals to prepare a regulatory submission of liposomal based drug delivery IND.
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