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https://www.sciencedirect.com/science/article/pii/S0169409X18301601
Nevertheless, oral drug delivery via pH polymer coatings, time dependent, pressure controlled systems can be particularly challenging because of the variations that occur in the absorption of drugs due to associated limitations such as variability in GI transit time, irregular pH changes, uncertain efficacy, inter-patient variability and less ...Author: Niranjan G. Kotla, Shubhasmin Rana, Gandhi Sivaraman, Omprakash Sunnapu, Praveen K. Vemula, Abhay Pa...
https://www.ncbi.nlm.nih.gov/pubmed/29966684
The present review focuses on major physiological gastro-intestinal tract challenges involved in altering the pharmacokinetics of delivery systems, pathophysiology of MH and fibrosis, reported drug-polysaccharide cargos and focusing on conventional to advanced disease responsive delivery strategies, highlighting their limitations and future ...Author: Niranjan G. Kotla, Shubhasmin Rana, Gandhi Sivaraman, Omprakash Sunnapu, Praveen K. Vemula, Abhay Pa...
https://onlinelibrary.wiley.com/doi/full/10.1002/adma.201806957
Mar 11, 2019 · A dual bioresponsive drug delivery depot is engineered, which can respond to the acidic pH and reactive oxygen species within the tumor microenvironment (TME), for codelivery of …Author: Huitong Ruan, Quanyin Hu, Quanyin Hu, Di Wen, Di Wen, Qian Chen, Qian Chen, Guojun Chen, Guojun Chen...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002303/
pH-sensitive drug delivery. pH-sensitive polymers (see Table Table1) 1) have garnered much attention in the fields of drug delivery [28,29], gene delivery [], and insulin delivery [].Generally, pH-sensitive polymers have weak acids or bases with pK a values between 3 and 10 [].Carboxylic, sulfonate, and primary or tertiary amino groups exhibit a change in ionization state as a function of pH.
https://www.nature.com/articles/natrevmats201675
Oct 25, 2016 · Bioresponsive materials capable of responding to specific biological cues hold vast promise for developing next-generation precision medications. This Review highlights recent advances in …Author: Yue Lu
https://jbioleng.biomedcentral.com/articles/10.1186/1754-1611-4-15
Nov 29, 2010 · For years, the field of drug delivery has focused on (1) controlling the release of a therapeutic and (2) targeting the therapeutic to a specific cell type. These research endeavors have concentrated mainly on the development of new degradable polymers and molecule-labeled drug delivery vehicles. Recent interest in biomaterials that respond to their environment have opened new methods …Author: Jin-Oh You, Dariela Almeda, George Jc Ye, Debra T Auguste
https://www.sciencedirect.com/science/article/pii/S0378517317311195
Similar self-regulated systems are also important in the treatment of other diseases including thrombosis and bacterial infection. In this review, we survey the recent advances in bioresponsive closed-loop drug delivery systems, including glucose-responsive, enzyme …Author: Jicheng Yu, Yuqi Zhang, Junjie Yan, Anna R. Kahkoska, Zhen Gu
https://www.tandfonline.com/doi/abs/10.1080/17425247.2018.1497607
Sep 06, 2018 · Expert opinion: Bioresponsive nanogels with an excellent stability and safety profile as well as fast response to biological signals are unique systems that mediate efficient and site-specific delivery of anticancer drugs, in particular macromolecular drugs like proteins, siRNA and DNA, leading to significantly enhanced tumor therapy compared ...Author: Dechun Huang, Hongliang Qian, Haishi Qiao, Wei Chen, Jan Feijen, Zhiyuan Zhong
https://memento.epfl.ch/event/bioresponsive-drug-delivery/
In this talk, I will discuss our ongoing efforts in developing physiological signal-triggered bioinspired drug delivery systems. I will first present the glucose-responsive synthetic systems for biomimetic delivery of insulin for diabetes treatment. Bioresponsive microneedle patches and vesicle fusion-mediated synthetic beta cells will be ...
https://link.springer.com/content/pdf/10.1186%2F1754-1611-4-15.pdf
REVIEW Open Access Bioresponsive matrices in drug delivery Jin-Oh You, Dariela Almeda, George JC Ye, Debra T Auguste* Abstract For years, the field of drug delivery has focused on (1) controlling the release of a therapeutic and (2) targeting theAuthor: Jin-Oh You, Dariela Almeda, George Jc Ye, Debra T Auguste
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