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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079258/
Mar 01, 2011 · Bioreducible polymers for gene delivery 1. Introduction. 2. Bioreducible polyethylenemines (PEIs). 3. Bioreducible polypeptides. 4. Bioreducible polyion complex (PIC) micelles. 5. Bioreducible poly (amido amine)s. 6. Conclusions.Author: Tae Il Kim, Sung Wan Kim, Sung Wan Kim
https://www.sciencedirect.com/science/article/pii/S1381514810002117
Bioreducible polymers, which possess mainly disulfide linkages in the polymer structures, have appeared as ideal gene delivery carriers due to the high stability in extracellular physiological condition and bioreduction-triggered release of genetic materials, as well as decreased cytotoxicity because intracellular cytosol is a reducing environment containing high level of reducing molecules such as …Author: Tae Il Kim, Sung Wan Kim, Sung Wan Kim
https://pubs.acs.org/doi/10.1021/ar200248u
Among the numerous multifunctional polymers that have been designed and evaluated as gene delivery vectors, polymers with redox-sensitive (or bioreducible) functional domains have gained great attention in terms of their structural and functional traits.Author: Sejin Son, Ran Namgung, Jihoon Kim, Kaushik Singha, Won Jong Kim
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142085/
Sep 28, 2014 · The works described in this review demonstrate current advances in the field of non-viral bioreducible polymers for therapeutic gene delivery to cardiovascular disease, anemia, diabetes, and cancer. The smart and advanced chemical modifications of bioreducible polymers will accelerate their progess toward human clinical application.Author: Young Sook Lee, Sung Wan Kim, Sung Wan Kim
https://www.researchgate.net/publication/51073220_Bioreducible_polymers_for_gene_delivery
Bioreducible polymers, which possess mainly disulfide linkages in the polymer structures, have appeared as ideal gene delivery carriers due to the high stability in extracellular physiological ...
https://pubs.acs.org/doi/abs/10.1021/acs.biomac.5b00590
Agmatine-containing bioreducible polymer, poly(cystaminebis(acrylamide)-agmatine) (poly(CBA-AG)) was synthesized for gene delivery systems. It could form 200–300 nm sized and positively charged polyplexes with pDNA, which could release pDNA in reducing the environment due to the internal disulfide bonds cleavage.Author: Ji-yeong Choi, Kitae Ryu, Gyeong Jin Lee, Kyunghwan Kim, Tae-il Kim
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