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https://dspace.library.uu.nl/bitstream/handle/1874/1737/full.pdf%3bsequence=1
1 BIOPHARMACEUTICAL ASPECTS OF ORAL DRUG DELIVERY IN DRUG RESEARCH AND DEVELOPMENT. 1.1 Introduction. 1.2 Drug Research and Development. 1.2.1 Preclinical and early clincial development. 1.2.2 Clinical development. 1.2.3 Registration. 1.2.4 Oral drug delivery. 1.3 Aim of thesis. 1.4 References. 2 PHYSICOCHEMICAL PROPERTIES REQUIRED FOR AN OPTIMAL
https://www.narcis.nl/publication/RecordID/oai%3Adspace.library.uu.nl%3A1874%2F1737
In the second study involving lymphatic drug delivery, the contribution of lymphatic absorption of testosterone undecanoate (TU), a very hydrophobic drug, to the systemic exposure of testosterone (T) was determined (chapter 6).Author: Werenfriedus Adrianus Faassen
https://core.ac.uk/display/39700501
Irrespective of the route of administration the same sequence of steps are of relevance for the exposure to a drug: release from the dosage form (dissolution), absorption into the blood (permeation through a biological membrane) and finally removal from the body (metabolism and elimination). \ud \ud The first part of this thesis focusses on the physicochemical properties of drugs.Author: Werenfriedus Adrianus Faassen
https://www.marketwatch.com/press-release/biopharmaceutical-oral-drug-delivery-market-growth-emerging-trends-and-future-opportunities-till-2027-top-keys-amgen-inc-catalent-inc-2019-11-25
Nov 25, 2019 · The global Biopharmaceutical oral Drug Delivery is segmented into Bio-pharmaceutics Delivery System (BCS) into Class I- High Solubility, High Permeability, Class II - Low Solubility, High ...
https://www.nature.com/articles/nrd.2018.183
Nov 30, 2018 · Although most of the successful biologics to date are drugs that bear a peptidic backbone, ranging from small peptides to monoclonal antibodies (~500 residues; 150 kDa), new biologic modalities, such as nucleotide-based therapeutics and viral gene therapies, are rapidly maturing towards widespread clinical use.Author: Aaron C. Anselmo, Yatin Gokarn, Samir Mitragotri
https://www.futuremarketinsights.com/reports/biopharmaceutical-oral-drug-delivery-market
Biopharmaceutical oral drug delivery market will be driven by patient compliance of these products. But there remain challenges of bioavailability of these products if given orally. If biopharmaceutical drugs are given orally, they will be degraded by enzymes and acidic environment in stomach and GI.3.3/5(23)
https://www.sciencedirect.com/science/article/pii/S1773224711500024
Finally, technical aspects of different capsule and filling technologies are addressed in order to connect the early biopharmaceutical considerations with aspects of the dosage form manufacture. Key words Oral drug absorption Self-emulsifying drug delivery systems (SEDDS) Dilution Dispersion Lipolysis Capsule compatibility REFERENCES 1. I.Author: M. Kuentz
http://www.biopharminternational.com/drug-delivery-systems-biopharmaceuticals
Aug 01, 2015 · Because of their nature, biopharmaceuticals are not easy to deliver via the oral route, explains Kate Hudson-Farmer, market insight strategist, Drug Delivery, Cambridge Consultants. A large proportion of these drugs are currently injected using intravenous infusion in the hospital, or increasingly in the home, she says.
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/oral-drug-delivery
Oral drug delivery is the most popular and economical route of drug administration. Barriers to oral drug delivery include solubility and dissolution, absorption, presystemic metabolism, and excretion.
https://clinicalgate.com/design-of-dosage-forms/
Biopharmaceutical aspects of dosage form design Biopharmaceutics can be regarded as the study of the relationship between the physical, chemical and biological sciences applied to drugs, dosage forms and drug action.
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