Biodegradable Polymer Gene Delivery

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Biodegradable Polymers for Gene Delivery

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832905/
    Oct 17, 2019 · Lack of biodegradation of polymeric gene delivery vehicles poses significant toxicity because of the accumulation of polymers in the tissue. Many attempts have been made to develop biodegradable polymers for gene delivery by modifying existing polymers and/or using natural biodegradable polymers.Author: T. J. Thomas, Heidar-Ali Tajmir-Riahi, C. K. S. Pillai

(PDF) Biodegradable Polymers for Gene Delivery

    https://www.researchgate.net/publication/336618986_Biodegradable_Polymers_for_Gene_Delivery
    This review summarizes mechanistic aspects of gene delivery and the development of biodegradable polymers for gene delivery. ... Although PEI is a non-biodegradable polymer, it is.

Biodegradable polymers and constructs: A novel approach in ...

    https://www.sciencedirect.com/science/article/pii/S0014305719305920
    Biodegradable polymer with their importance is summarized in Table 1. The most important property of such polymers as the name suggests is their biodegradation, producing substances which neither harm to the body nor the environment on excretion from the body. ... Collagen also has applications in plasmid DNA delivery and gene delivery in ...Author: Shiv Kumar Prajapati, Ankit Jain, Aakanchha Jain, Sourabh Jain

Engineering biodegradable and multifunctional peptide ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015834/
    Oct 24, 2013 · Engineering biodegradable and multifunctional peptide-based polymers for gene delivery ... and degradability on gene transfer, as well as the impact of multivalency and polymer architecture on peptide bioactivity. Keywords: Nonviral gene ... gene delivery to the CNS using nonviral vectors has not been successful due to the low transfection ...Author: Julie Shi, Joan G Schellinger, Suzie H Pun

A novel gene delivery composite ... - Scientific Reports

    https://www.nature.com/articles/srep21402
    Feb 17, 2016 · We concluded the folate-poly (ester amine) (FA-PEA) polymer would be useful for targeted gene delivery, and the novel gene delivery composite …Author: Yi Yang, Hang Zhao, YanPeng Jia, QingFa Guo, Ying Qu, Jing Su, XiaoLing Lu, YongXiang Zhao, ZhiYong ...

Biodegradable polymers as non-viral carriers for plasmid ...

    https://www.sciencedirect.com/science/article/pii/S0168365907006220
    2.1. Polyesters. Water-soluble cationic polyamine polyesters may be potentially very useful for the delivery of DNA, since they are able to form polyion complexes with DNA and may degrade quite rapidly .Poly(4-hydroxy-l-proline ester) (PHP, Fig. 1) was the first water-soluble poly-cationic biodegradable polymer used as a gene carrier, as reported independently by Park et al. and Langer et al. .Author: Jordy Luten, Cornelus F. van Nostrum, Stefaan C. De Smedt, Wim E. Hennink

Development of a Safe Gene Delivery System Using ...

    https://pubs.acs.org/doi/10.1021/ja001033h
    Jun 23, 2000 · Biodegradable polymer-based interleukin-12 gene delivery: role of induced cytokines, tumor infiltrating cells and nitric oxide in anti-tumor activity. Gene Therapy 2002, 9 (16) , 1075-1084. DOI: 10.1038/sj.gt.3301766. Cheol-Hee Ahn, Su Young Chae, You Han Bae, Sung Wan Kim.Author: Yong Beom Lim, Chang Hwan Kim, Kwan Kim, Sung Wan Kim, Jong Sang Park

(PDF) Biodegradable Polymers: Medical Applications

    https://www.researchgate.net/publication/301294609_Biodegradable_Polymers_Medical_Applications
    been used in gene delivery, drug delivery, and in tissue engineering applications (31). PPE and its copolymers can form films, gels, micelles, and partic les (1).

Biodegradable and Nontoxic Nanogels as Nonviral Gene ...

    https://pubs.acs.org/doi/10.1021/bc300314u
    The development of polymeric systems with tailored properties as nonviral gene carriers continues to be a challenging and exciting field of research. We report here the synthesis and characterization of biodegradable, temperature- and pH-sensitive carbohydrate-based cationic nanogels as effective gene delivery carriers to Hep G2 cells. The temperature-sensitive property of the nanogels allows ...Author: Rajesh Sunasee, Phanphen Wattanaarsakit, Marya Ahmed, Farahnaz Begum Lollmahomed, Ravin Narain

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