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http://microspheres.us/drug_delivery/motivations-biodegradable-microspheres-drug-delivery/187.html
In recent years there is significant interest in using biodegradable polymeric microspheres for drug delivery. Delivering drugs through biodegradable microspheres has numerous advantages compared to conventional delivery systems.
https://www.ncbi.nlm.nih.gov/pubmed/8521523
General aspects of biodegradable microspheres prepared from natural and synthesized polymers used in drug delivery systems are reviewed first from various viewpoints: characteristics of biodegradable polymers (physicochemical properties, bioerosion mechanism, biocompatibility), preparation method for the microspheres, drug release from parenteral products and briefly nonparenteral products.Author: Hiroaki Okada, Hajime Toguchi
https://www.ncbi.nlm.nih.gov/pubmed/25687105
Selection of biodegradable polymers and formulation techniques to create microspheres is the biggest challenge in research. In the near future, biodegradable microspheres will become the eco-friendly product for drug delivery of various genes, hormones, proteins and peptides at specific site of body for desired periods of time.Author: Vipul D Prajapati, Girish K Jani, Jinita R Kapadia
https://www.sciencedirect.com/science/article/abs/pii/S0169409X01002009
Currently, several kinds of polymer devices for drug delivery to the posterior segment of the eye are under clinical use, or under investigation. Among these devices, microparticulates, such as microspheres, provide an alternative to multiple injections to obtain sustained release of the drug with a single administration.Author: Rocio Herrero-Vanrell, Miguel F Refojo
https://www.sciencedirect.com/science/article/pii/B978044482027350016X
In summary, we can see that drug delivery us ing biodegradable microspheres provides poten tial methods for treating various diseases, and we are looking at additional applications of this microsphere technique with other peptides, pro teins and chemical drugs.Author: Hiroaki Okada, Masaki Yamamoto, Toshiro Heya, Yayoi Inoue, Shigeru Kamei, Yasuaki Ogawa, Hajime Togu...
https://www.sciencedirect.com/science/article/pii/S0169409X01002009
Among the biodegradable polymers that have been investigated to make microparticles for drug delivery are gelatin, albumin, polyortho-esters, polyanhydrides, and polyesters, particularly polymers of d, l and dl -lactic acid [also known as poly (lactic acid), polylactide or PLA] and poly (glycolic acid) [poly (glicolide), PGA],...Author: Rocio Herrero-Vanrell, Miguel F Refojo
https://www.sciencedirect.com/science/article/pii/S0168365903001949
In systemic delivery of proteins, biodegradable microspheres as parenteral depot formulation occupy an important place because of several aspects like protection of sensitive proteins from degradation, prolonged or modified release, pulsatile release patterns.Author: V.R. Sinha, Aman Trehan
https://www.researchgate.net/publication/11679477_Biodegradable_microspheres_for_vitreoretinal_drug_delivery
In the near future, biodegradable microspheres will become the eco-friendly product for drug delivery of various genes, hormones, proteins and peptides at specific site of body for desired periods...
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