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https://www.tandfonline.com/doi/abs/10.3109/1061186X.2010.504268
Aug 12, 2014 · Drug delivery to ocular region is a challenging task. Only 1–2% of drug is available in eye for therapeutic action, rest of the drug is drained out through nasolachrymal drainage system and other ocular physiological barriers. To overcome these problems of conventional dosage form, novel drug delivery systems are explored like nanoparticles.Author: Himanshu Gupta, M. Aqil, R. K. Khar, Asgar Ali, Aseem Bhatnagar, Gaurav Mittal
https://www.researchgate.net/publication/45460214_Biodegradable_levofloxacin_nanoparticles_for_sustained_ocular_drug_delivery
Drug delivery to ocular region is a challenging task. Only 1-2% of drug is available in eye for therapeutic action, rest of the drug is drained out through nasolachrymal drainage system and other ocular physiological barriers. To overcome these problems of conventional dosage form, novel drug delivery systems are explored like nanoparticles.
https://www.researchgate.net/profile/Gaurav_Mittal6/publication/45460214_Biodegradable_levofloxacin_nanoparticles_for_sustained_ocular_drug_delivery/links/02bfe5108a8233b13b000000.pdf
Biodegradable levooxacin nanoparticles for sustained ocular drug delivery Himanshu Gupta 1,2 , M. Aqil 1 , R. K. Khar 1 , Asgar Ali , Aseem Bhatnagar 2 , and Gaurav Mittal
https://www.academia.edu/10587265/Biodegradable_levofloxacin_nanoparticles_for_sustained_ocular_drug_delivery
The optimized formulation was Journal of Drug Targeting Biodegradable levofloxacin nanoparticles for ocular drug delivery 413 selected on the basis of small particle size, less PI and with same charges avoids aggregation (Feng & Huang, high entrapment efficiency with maximum nanoparticle …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693026/
Jun 18, 2013 · Ocular drug transport barriers pose a challenge for drug delivery comprising the ocular surface epithelium, the tear film and internal barriers of the blood-aqueous and blood-retina barriers. Ocular drug delivery efficiency depends on the barriers and the clearance from the choroidal, conjunctival vessels and lymphatic.Author: Hong-Yan Zhou, Ji-Long Hao, Shuang Wang, Yu Zheng, Wen-Song Zhang
https://www.sciencedirect.com/science/article/pii/S1359028602001171
As previously stated, PLGA has been the most common polymer used to make biodegradable nanoparticles, however, these are clearly not the optimal carrier for all drug delivery applications. For each application and drug, one must evaluate the properties of the system (drug and particle) and determine whether or not it is the optimal formulation for a given drug delivery application.Author: M.L Hans, A.M Lowman
https://www.sciencedirect.com/science/article/pii/S1549963409001920
Much of the published data suggests that in the case of ophthalmic drug delivery, an appropriate particle size and a narrow size range, ensuring low irritation, adequate bioavailability, and compatibility with ocular tissues, should be sought for every suspended drug.13, 14 Hence, the best known class of biodegradable polymers for sustained drug delivery is poly(dl-lactide-co-glycolide) (PLGA).Author: Himanshu Gupta, Himanshu Gupta, Mohammed Aqil, Roop K. Khar, Asgar Ali, Aseem Bhatnagar, Gaurav Mitt...
http://www.asiapharmaceutics.info/index.php/ajp/article/viewFile/93/207
potential (+37.2 to +43.5 mV). The encapsulation efficiency and loading capacity were 65–83% and 15–25%, respectively. The levofloxacin-loaded chitosan nanoparticles displayed more crystallinity than levofloxacin. of levofloxacin from the nanoparticles showed a sustained release of the drug over a period of 20 h.
https://www.semanticscholar.org/paper/Formulation-Development-and-Characterization-of-of-Verma-Doshi/a38fa189de238cf3def1d63e81484727a8fdf2c5
This study assessed the feasibility of using nanostructured lipid matrices (NLM) for ocular delivery of levofloxacin hemihydrate adopting heterolipids composed of mixtures of lipid and stabilized by surfactant. The systems were prepared using the modified …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289909/
Concentration of drug available in the precorneal area acts as a driving force for its passive diffusion across cornea. However, for efficient ocular drug delivery with eye drops, high corneal permeation with longer drug cornea contact time is required. Several efforts have been made toward improving precorneal residence time and corneal penetration.Author: Ashaben Patel, Kishore Cholkar, Vibhuti Agrahari, Ashim K Mitra
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