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https://journals.lww.com/anesthesia-analgesia/pages/articleviewer.aspx?year=2004&issue=06000&article=00006&type=Fulltext
pment for use in humans are issues pertinent to safety and the preclinical reports that have increased our understanding of intrathecal midazolam toxicity. We seek to emphasize the time course of these studies and how they merged to provide enabling data that drove the clinical implementation. In the case of midazolam, we point to the potential issues that arose when preclinical safety data ...
https://www.asra.com/page/226/perioperative-management-of-patients-with-intrathecal-drug-delivery-systems
Perioperative management of patients with an intrathecal drug delivery system for chronic pain. Anesth Analg 2008; 107(4): 1393-6. Singh H, Kundra S, Singh RM, Grewal A, Kaul TK, Sood D. Preemptive analgesia with ketamine for laparoscopic cholecystectomy.
https://www.researchgate.net/publication/259845012_Best_Practices_for_Intrathecal_Drug_Delivery_for_Pain
The objective of this study was to identify best practices and provide guidance to clinicians to ensure safety and optimize intrathecal drug delivery for chronic intractable pain.
https://www.drugs.com/uk/lioresal-intrathecal-injection-50micrograms-1ml-leaflet.html
Patient information for LIORESAL INTRATHECAL INJECTION 50MICROGRAMS/1ML Including dosage instructions and possible side effects. ... weakness or those being treated with benzodiazepine-type preparations or opiates, who are at higher risk of respiratory depression. ... infection or catheter malplacement can also lead to drug delivery failure ...
http://www.carolinapain.org/wp-content/uploads/2015/10/SAT-AM_Hatheway.pdf
Intrathecal Opioids Patient Selection Low dose clinical studies CSF Flow Optimal dosing strategy for intrathecal drug delivery, in general Optimal dosing strategy for Micro-dosing intrathecal drug delivery ... Overlapping painkiller and benzodiazepine prescriptions
https://journals.lww.com/anesthesia-analgesia/Fulltext/2004/06000/Safety_of_Continuous_Intrathecal_Midazolam.5.aspx
Midazolam is a commonly used drug for preoperative sedation in anesthesia induction, and its anxiolytic, amnestic, and hypnotic effects have been well described. Recent interest now focuses on intrathecal infusion of this benzodiazepine as an alternative to opioids for the treatment of intractable pain of neuropathic origin.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398634/
May 30, 2012 · In animal studies, researchers have been able to show that intrathecal midazolam by binding to benzodiazepine receptors in the spinal cord increases the threshold for pain. In a more recent study, Sen and colleagues reported that in women with caesarean section delivery, intrathecal midazolam (2 mg) when added to 1.5 ml of 5% lignocaine showed ...Author: A Karbasfrushan, K Farhadi, J Amini-Saman, S Bazargan-Hejazi, A Ahmadi
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349402/
Spasticity is a velocity-dependent increase in muscle tone and uncontrolled, repetitive, involuntary contractions of skeletal muscles. Spasticity presents as upper motor neuron symptoms in patients with central nervous system pathology such as stroke, spinal cord injury, brain injury, or multiple sclerosis.Author: Eric Y. Chang, Nilasha Ghosh, Daniel Yanni, Sujin Lee, Daniela Alexandru, Tahseen Mozaffar
https://www.researchgate.net/publication/9071911_Intrathecal_drug_delivery_2002
Background Intrathecal drug delivery has been used clinically since the 1970’s. Significant clinical advances have been made combining new technology with pharmacology and surgery.Author: Michael S Turner
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