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https://www.tandfonline.com/doi/pdf/10.3109/02656736.2012.668639
developments and limitations of these techniques for drug and gene delivery in vitro and in vivo are explored. The combination of ultrasonic and magnetic techniques is also reviewed with particular focus on magnetic microbubbles as delivery agents with the potential to combine the advantages of both methods whilst addressing many of their limitations.
https://www.researchgate.net/publication/225057793_Magnetic_targeting_and_ultrasound_mediated_drug_delivery_Benefits_limitations_and_combination
Magnetic targeting and ultrasound mediated drug delivery: Benefits, limitations and combination ... reviewed with particular focus on magnetic microbubbles as delivery agents with the potential to ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517817/
Nov 01, 2012 · Treatment with TSL+heat to local tumors can be thought of as the fusion of two traditional approaches to drug delivery: 1) continuous infusion of drug and 2) nanoparticle encapsulation. Drug infusions maintain elevated drug levels in the bloodstream and thus prevent drug washout from the tumor prior to cellular uptake . However, this approach does not provide any tumor selectivity.Author: Ashley A. Manzoor, Lars H. Lindner, Chelsea D. Landon, Ji-Young Park, Andrew J. Simnick, Matthew R. ...
https://www.sciencedirect.com/science/article/pii/S1748013207700841
Limitations of magnetic drug delivery Since the magnetic gradient decreases with the distance to the target, the main limitation of magnetic drug delivery relates to the strength of the external field that can be applied to obtain the necessary magnetic gradient to control the residence time of NPs in the desired area or which triggers the drug desorption.Author: Manuel Arruebo, Rodrigo Fernández-Pacheco, M. Ricardo Ibarra, Jesús Santamaría
https://www.jgtps.com/admin/uploads/YqxI0h.pdf
Adhesion of drug delivery device to the mucosal membrane such as buccal, ocular, rectal, nasal etc can be termed as bio adhesion. These kinds of microspheres exhibit a prolonged residence time at the site of application and causes intimate contact with the absorption site and produces better therapeutic action.File Size: 1MB
https://www.tandfonline.com/doi/abs/10.1517/17425240802662795
Sep 21, 2010 · Background: Magnetic vehicles are very attractive for delivery of therapeutic agents as they can be targeted to specific locations in the body through the application of a magnetic field gradient.The magnetic localization of a therapeutic agent results in the concentration of the therapy at the target site consequently reducing or eliminating the systemic drug side effects.Author: Boris Polyak, Gary Friedman
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527668/
The aims for nanoparticle entrapment of drugs are either enhanced delivery to, or uptake by, target cells and/or a reduction in the toxicity of the free drug to non-target organs. Both situations will result in an increase of therapeutic index, the margin between the doses resulting in a therapeutic efficacy (eg,...Author: Wim H De Jong, Paul Ja Borm
https://notesmatic.com/2018/07/applications-advantages-and-disadvantages-of-nanotechnology/
Aug 26, 2019 · Targeted drug delivery using nano particles is highly effective. Apart from minimal side effects, it is also less costly and has low toxic effect on the other organs. Nanotechnology has also been found to be highly effective in anticancer therapy.
https://www.researchgate.net/publication/281282862_Advantage_and_Disadvantage_in_Drug_Delivery_Systems
Apr 10, 2011 · Nanotechnology advances in drug delivery deal with the development of synthetic nanometer sized targeted delivery systems for therapeutic agents Currently used drug delivery systems, such as liposomes, micelles, nanoemulsions, polymeric nanoparticles and many others demonstrate a broad variety of useful properties.
https://www.leaf.tv/articles/advantages-disadvantages-of-the-food-delivery-system/
One of the largest disadvantages to food delivery systems is the price. When the food is ordered for more than one person, the expense is typically equal to eating out at a nice restaurant every night. Many food delivery systems cost upwards of $20 per day per person.
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