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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956587/
Peptides and proteins are readily metabolized in the GI tract, and the hydrophilic nature of most natural peptides restricts movement across the epithelial barrier. Advances in the oral delivery of proteins and peptides have been made by the use of absorption enhancers, enzyme inhibitors and direct structural modification of the therapeutic.Author: Benjamin J Bruno, Geoffrey D Miller, Carol S Lim
https://www.nature.com/articles/s41578-019-0156-6
Dec 24, 2019 · Fig. 2: Physiological barriers to oral protein and peptide delivery. Fig. 3: Mechanisms of action of materials used for oral drug delivery. Fig. 4: Materials used for oral protein and peptide ...Author: Tyler D. Brown, Tyler D. Brown, Kathryn A. Whitehead, Samir Mitragotri, Samir Mitragotri
https://www.ncbi.nlm.nih.gov/pubmed/7600588
Lysosomal peptidases will also present a barrier to any peptides or proteins endocytosed by the epithelial cells. Although the colon has received some attention as a possible site for peptide delivery, evidence shows that the lumen of the colon contains substantial amounts of peptidase activity, largely because of enzyme production by microorganisms.Author: Woodley Jf
http://www.gbv.de/dms/bs/toc/122140982.pdf
3. Dermal Barriers to Peptide/Protein Delivery 183 3.1. Metabolic/Enzymatic Barrier 183 3.2. Physical Barrier 184 3.3. Microbial Barrier 185 4. Strategies for Dermal Delivery of Peptides/Proteins 185 4.1. Noninvasive Delivery through Intact Skin 186 4.2. Invasive Delivery through Broken Skin 191 5. Drug Delivery Design 193 6.
https://www.slideshare.net/ManoharKengar/protein-peptide-drug-delivery-system-barrier
Nov 16, 2017 · To cross the capillary endothelium the peptides/proteins must pass between the cells or alternatively transverse across the endothelial cells themselves. Solutes that transverse the endothelial cell membrane may get modified or metabolized by cytoplasmic enzymes. Thus, the endothelial passage poses metabolic or enzymatic barrier to the solution passage. 16/11/2017 16
https://www.sciencedirect.com/science/article/pii/B9780128179093000169
The disadvantages associated with the use of microsphere delivery systems for the delivery of therapeutic proteins and peptides are mainly related to the stability of the incorporated proteins and peptides because denaturation of proteins can occur leading to loss of biological activity.Author: Pran Kishore Deb, Omar Al-Attraqchi, Balakumar Chandrasekaran, Anant Paradkar, Rakesh K. Tekade
https://www.researchgate.net/publication/319122467_An_over_view_Protein_and_peptide_based_drug_delivery
Proteins are polymers consisting of amino acids covalently linked by peptide bonds. Peptides are small proteins composed of up to a few dozen amino acids proteins are rapidly degraded by digestive enzymes. Till recently, injections (i.e. intravenous, intramuscular or subcutaneous route)...
https://innovareacademics.in/journal/ijcpr/Issues/Vol3Issue2/286.pdf
Barriers (1)to protein drug delivery: Enzymatic barrier Limits absorption of protein drugs from G.I. tract. Intestinal epithelial barrier Involved in the transport of protein drugs across the intestinal epithelium.
https://www.slideshare.net/BrajeshKumar67/protein-and-peptide-drug
May 24, 2015 · 1. Protein & Peptides PROTEINS: Proteins are the large organic compounds made of amino acids arranged in a linear chain and joined together by peptide bonds. Protein > 50 amino acids PEPTIDES: These are short polymers formed from the linking, in a defined order of amino acids. peptide < 50 amino acids 3 4.
https://www.sciencedirect.com/book/9780123849359/peptide-and-protein-delivery
The aim of this chapter is to look at the use of amphiphilic polyelectrolytes and chemically modified chitosan for the gastrointestinal delivery of proteins and peptides, and to discuss how the chemical modifications have impacted on the two important challenges in oral protein/peptide delivery, i.e., protection against intestinal enzymatic degradation and promotion of protein/peptide transport …
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