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https://drug-dev.com/nasal-delivery-a-promising-route-of-drug-delivery-to-the-brain-scientific-considerations-2/
The presence of enzymes in the nasal cavity can form an enzyme barrier that is known to affect the stability of the drug in the nasal cavity. Proteins and peptides are prone to degradation by proteases and amino-peptidase within the nasal cavity.
https://www.sciencedirect.com/science/article/pii/B9780128197127000152
The method is non-invasive and provides direct drug transfer from nose to brain via olfactory nerve, hence it bypasses the blood-brain barrier for CNS effect and first pass effect while drug absorbed via nasal mucosa for systemic effect.
https://www.ondrugdelivery.com/wp-content/uploads/2018/11/Nov2005.pdf
become the dominant delivery principle in nasal drug delivery. Direct-Haler is the first drug deliv-ery company to take advantage of this device-dependent reflex for enhancing nasal drug deliv-ery. Naturally, the increased interest in this princi-ple for enhanced nasal delivery has recently led other companies to seek exploitation of the same
https://www.3m.com/3M/en_US/drug-delivery-systems-us/technologies/nasal/
Your patients deserve better nasal drug delivery than aqueous nasal sprays for allergic rhinitis. These sprays can drip down the throat and out of the nose, causing irritation, embarrassment, and unpleasant aftertastes. 3M can help deliver your treatments with intuitive patient-friendly nasal MDIs.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930669/
Nov 26, 2019 · The application of NP for the direct enhancement of drug delivery from the nasal cavity to the brain demonstrates great potential. The encapsulation of drugs into NP can overcome some of the problems related to intranasal administration (e.g., the poor capacity of penetration through the nasal mucosa, the rapid mucociliary clearance, and the ...Author: Franciele Aline Bruinsmann, Gustavo Richter Vaz, Aline de Cristo Soares Alves, Tanira Aguirre, Adria...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2604883/
Dec 10, 2008 · Intranasal delivery provides a practical, non-invasive method of bypassing the blood-brain barrier (BBB) to deliver therapeutic agents to the brain and spinal cord. This technology allows drugs that do not cross the BBB to be delivered to the central nervous system within minutes.Author: Leah R Hanson, William H Frey, William H Frey
http://www.thepharmajournal.com/vol2Issue1/Issue_march_2013/14.pdf
The major problem in drug delivery to brain is the presence of the BBB1. Brain is tightly segregated from the circulating blood by a membranous barrier called the Blood Brain Barrier (BBB) 2,3. The major challenge in CNS drug delivery is the blood-brain barrier (BBB), which limits the access of most drugs …
https://www.thepharmaeducation.com/2020/04/Nasal-Drug-Delivery-System.html
The Pharma Education Network is an interactive platform has been created with the aim to provide information and support to the pharmacy students and pharmaceutical professionals.
https://www.researchgate.net/publication/49601002_Nasal_drug_delivery_system_-_an_overview
BARRIERS TO NASAL ABSORPTION Nasal drug delivery system is considered has a profit a- ble route for the formulation scientist because it has easy and simple formulation strategies.
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