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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1440473/
Gene delivery to neural cells is central to the development of transplantation therapies for neurological diseases. In this study, we used a baculovirus derived from the domesticated silk moth, Bombyx mori, as vector for transducing a human cell line (HEK293) and primary cultures of rat Schwann cells. Under optimal conditions of infection with a recombinant baculovirus containing the reporter green fluorescent protein gene under mammalian promoter control, the infected cells …Author: Christos Kenoutis, Rodica C. Efrose, Luc Swevers, Alexandros A. Lavdas, Maria Gaitanou, Rebecca Mats...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC39799/
Mar 19, 1996 · This paper describes the use of the baculovirus Autographa californica multiple nuclear polyhedrosis virus (AcMNPV) as a vector for gene delivery into mammalian cells. A modified AcMNPV virus was prepared that carried the Escherichia coli lacZ reporter gene under control of the Rous sarcoma virus promoter and mammalian RNA processing signals.Author: F. M. Boyce, N. L. R. Bucher
https://www.ncbi.nlm.nih.gov/pubmed/14970604
A relatively recent advance in the use of recombinant baculoviruses is their use for delivery of genes and genetic elements into mammalian cells. Baculovirus vectors retrofitted with mammalian gene promoters have been shown to efficiently deliver and express genes in a broad assortment of cell types.Author: Raymond V. Merrihew, Thomas A. Kost, J. Patrick Condreay
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411692/
Apr 22, 2015 · Though immunoprivileged areas seem to suit best for baculovirus-mediated gene delivery, direct injection of recombinant baculoviruses into quadriceps femoris muscle of mice resulted in a transient expression of the marker gene . In rats, intramuscularly injected baculovirus was used to treat hyperammonemia .Author: Kaisa-Emilia Makkonen, Kari Airenne, Seppo Ylä-Herttulala
https://www.sciencedirect.com/science/article/pii/S0168165607004130
Recombinant baculoviruses have emerged as a new gene delivery vehicle for mammalian cells. Thus, a shuttle promoter that mediates gene expression in both insect and mammalian cells will facilitate the development of a baculovirus vector-based mammalian cell gene delivery vehicle.Author: Hui Gao, Hui Gao, Yu Wang, Na Li, Wu-Ping Peng, Yuan Sun, Guang-Zhi Tong, Hua-Ji Qiu
https://www.cell.com/trends/biotechnology/fulltext/S0167-7799(01)01911-4
Apr 01, 2002 · Recombinant baculoviruses provide a powerful tool for delivery of foreign genes into mammalian cells. Viruses can be generated and produced to high titers in insect cells for transduction into mammalian cells. As outlined in Box 1, recombinant baculoviruses possessAuthor: Thomas A. Kost, J.Patrick Condreay
https://www.nature.com/articles/ncomms11529
May 04, 2016 · Multigene delivery systems also allow reprogramming of somatic cells to stem cells 6 or to specifically differentiated cell lines 7. The construction of complex multigene circuits in mammalian cells is a core concept in synthetic biology requiring the flexible generation of modular multigene expression systems 8,9.Author: Maysam Mansouri, Itxaso Bellon-Echeverria, Aurélien Rizk, Zahra Ehsaei, Chiara Cianciolo Cosentino, ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610534/
May 05, 2005 · Baculovirus-mediated gene delivery in mammalian cells The successful use of recombinant baculoviruses to direct gene expression in mammalian cells was first reported ten years ago 93 , 94 . Since we reviewed this subject 95 there has been a remarkable increase in published reports of the use of this system.Author: Thomas A Kost, J Patrick Condreay, Donald L Jarvis
http://onlinelibrary.wiley.com/doi/10.1002/bit.20213/abstract
Although baculovirus‐mediated gene delivery into mammalian cells has been documented in a wealth of the literature, systematic investigation of the optimal transduction conditions remains unavailable. In this work, a transduction protocol using unconcentrated baculovirus is proposed for simple and efficient gene delivery into HeLa cells.
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