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https://www.researchgate.net/publication/5516568_Baculoviral_Vectors_for_Gene_Delivery_A_Review
Baculoviral vectors are presented as a safe class of gene delivery vectors because they do not replicate nor cause any toxicity in mammalian cells (Hu, 2008; Wang and Balasundaram, 2010). To ...Author: Yu-Chen Hu
http://www.eurekaselect.com/66463/article
Baculovirus has emerged as a novel vector for in vivo and in vitro gene delivery. In addition, the applications of baculovirus-mediated gene transfer have been explosively expanded to drug screening, eucaryotic gene display, cancer therapy and tissue engineering, etc.Author: Yu-Chen Hu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610534/
May 05, 2005 · The use of recombinant baculoviruses containing mammalian cell–active expression cassettes, commonly referred to as BacMam viruses, for gene delivery to mammalian cells was first demonstrated in cells of liver origin 93,94. Subsequently, a number of labs reported gene delivery to a broad range of nonhepatic cell lines and primary cells 96,97,98.Author: Thomas A Kost, J Patrick Condreay, Donald L Jarvis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835104/
Mar 31, 2009 · Baculovirus is a promising gene delivery vector but its widespread application is impeded as it only mediates transient transgene expression in mammalian cells. To prolong the expression, we developed a dual baculovirus system whereby one baculovirus expressed FLP recombinase while the other harbored an Frt-flanking cassette encompassing the transgene and oriP / EBNA1 derived from …Author: Wen-Hsin Lo, Shiaw-Min Hwang, Ching-Kuang Chuang, Chi-Yuan Chen, Yu-Chen Hu
https://www.sciencedirect.com/science/article/pii/S2329050116301401
To use BV vectors for human gene therapy, the development of robust, reliable, and scalable production processes for the vectors is crucial. This review discusses the current knowledge on the manufacturability of Ac MNPV BV vectors for clinical use.Author: Timothy Weixin Kwang, Xinhui Zeng, Shu Wang
https://www.ncbi.nlm.nih.gov/pubmed/30235841
Sep 19, 2018 · Based on its ability to express high levels of protein, baculovirus has been widely used for recombinant protein production in insect cells for more than thirty years with continued technical improvements. In addition, baculovirus has been successfully applied for foreign gene delivery into mammalian cells without any viral replication.Author: Chikako Ono, Toru Okamoto, Takayuki Abe, Yoshiharu Matsuura
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616530/
Feb 26, 2013 · Effective transduction and high-level transgene expression mediated by baculoviral vectors are especially suited for cancer gene therapy. Baculoviral vectors armed with suicide genes, tumor suppressor genes, proapoptotic genes, immunopotentiating genes, and antiangiogenesis genes have been tested in vivo in animal tumor models in many different anticancer regimens. 27,54,115 …Author: Kari J Airenne, Yu-Chen Hu, Thomas A Kost, Richard H Smith, Robert M Kotin, Chikako Ono, Yoshiharu M...
https://www.cell.com/molecular-therapy-family/methods/fulltext/S2329-0501(16)30140-1
Jan 01, 2016 · To use BV vectors for human gene therapy, the development of robust, reliable, and scalable production processes for the vectors is crucial. This review discusses the current knowledge on the manufacturability of Ac MNPV BV vectors for clinical use.Author: Timothy Weixin Kwang, Xinhui Zeng, Shu Wang
https://pubs.acs.org/doi/10.1021/cr800409e
Dec 03, 2008 · Polyelectrolyte Complexes of Low Molecular Weight PEI and Citric Acid as Efficient and Nontoxic Vectors for in Vitro and in Vivo Gene Delivery. Bioconjugate Chemistry 2016 , 27 (3) , 549-561.Author: Meredith A. Mintzer, Eric E. Simanek
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