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https://www.nature.com/articles/3302635
Sep 15, 2005 · Although the procedure of bacterial gene delivery is far from being definitely solved, bactofection remains a promising technique for transfection in human gene therapy.Author: R Pálffy, R Gardlík, J Hodosy, M Behuliak, P Reško, J Radvánský, P Celec
https://www.creative-biolabs.com/gene-therapy/development-of-bacteria-as-gene-delivery-system.htm
Bacteria become an attractive gene delivery vector because it can transfer therapeutic gene product into the target organism, organ or tissue directly. Creative Biolabs provides the state-of-the-art non-viral vector technology for basic research and preclinical applications.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725396/
Over the last decade, delivery of plasmid DNA into mammalian cells using virulence-attenuated bacteria has emerged as an alternative approach for genetic vaccination and gene therapy. The term ‘bactofection’ has been applied to describe bacteria-mediated gene transfer into mammalian cells.Author: Mdb D. B. Larsen, U. Griesenbach, S. Goussard, Dc C. Gruenert, Dc C. Gruenert, Dm M. Geddes, Rk K. S...
https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.5b00172
Bactofection offers a gene delivery option particularly useful in the context of immune modulation. The bacterial host naturally attracts recognition and cellular uptake by antigen presenting cells (APCs) as the initial step in triggering an immune response.Author: Tai-Chun Chung, Charles H. Jones, Akhila Gollakota, Mahmoud Kamal Ahmadi, Snehal Rane, Guojian Zhang...
https://www.nature.com/articles/s41417-018-0039-9
Aug 13, 2018 · One mechanism that has been used to carry this out is the process of bactofection where post-invasion, bacteria deliver plasmid-borne mammalian genes …Author: Síle A. Johnson, Michael J. Ormsby, Anne McIntosh, Stephen W. G. Tait, Karen Blyth, Daniel M. Wall
https://www.cell.com/molecular-therapy-family/molecular-therapy/pdf/S1525-0016(06)01042-2.pdf
To assess, if bactofection leads to gene expression in vivo, mice were infected with invasive E. coli carrying pCIKLux (5x10 7 - 5x10 9 ... important role for nonviral aerosol gene delivery which should be considered in transgenic animal mouse models of inherited and acquired diseases for aerosol gene delivery studies.
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