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https://clinicaltrials.gov/ct2/show/NCT00694785
Jun 10, 2008 · Patients will receive a total dose of approximately 1.4 mg/kg of ARC1779 over 72 hours to achieve a target plasma concentration of 3 mcg/mL. The infusion of ARC1779 will be tapered by 50% from 48 hours to 60 hours and again by 50% from 60 hours to 72 hours.Allocation: Randomized
https://clinicaltrials.gov/ct2/show/NCT00507338
Jul 26, 2007 · James Gilbert, MD/Chief Medical Officer, Archemix, Corp. ClinicalTrials.gov Identifier: NCT00507338 Other Study ID Numbers: ARC1779-003 : First Posted: July 26, 2007 Key Record Dates: Last Update Posted: January 9, 2009 Last Verified: January 2009Allocation: Randomized
https://www.basepairbio.com/enhancing-aptamer-stability/
Due to an observed decrease in potency of serum nucleases over time, extended half-life was estimated based on results for the first 24 hours.3 Researchers at Archemix found that an RNA aptamer with some 2’-O-methyl substitutions was stable for >24 hours in 95% rat plasma and an aptamer with full 2’-O-methyl substitutions was stable for up to 96 hours. 2Estimated Reading Time: 11 mins
https://www.massdevice.com/baxter-acquires-hemophilia-assets-wins-ide-hemodialysis-system/
Nov 20, 2010 · Baxter International Inc. (NYSE:BAX) notched a pair of wins over the past 24 hours, acquiring Archemix Corp.'s hemophilia assets and winning an investigational device exemption for a …
https://www.ncbi.nlm.nih.gov/pubmed/18025536
Dec 04, 2007 · In terms of pharmacokinetics, the concentration-time profile of ARC1779 appeared monophasic. The observed concentration and area under the curve were dose proportional. The mean apparent elimination half-life was approximately 2 hours, and mean residence time was approximately 3 …
https://www.realdealdocs.com/viewdocument.aspx?DocumentID=2252091
Isis will have the right to have an independent certified public accounting firm of nationally recognized standing, reasonably acceptable to Archemix, have access during normal business hours, and upon reasonable prior written notice, to Archemix’s records as may be reasonably necessary to verify the accuracy of Net Sales or Sublicense ...
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