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https://academic.oup.com/ofid/article/4/suppl_1/S272/4294658#:~:text=An%20antibiotic%20time%20out%20%28ATO%29%20at%2048%E2%80%9372%20hours,appropriateness%20including%20the%20need%20for%20de-escalation%20and%20discontinuation.
https://academic.oup.com/ofid/article/4/suppl_1/S272/4294658
Background. An antibiotic time out (ATO) at 48–72 hours is a critical component of antimicrobial stewardship programs to improve judicious antibiotic use. It is a strategy to prompt clinicians to re-evaluate antibiotic appropriateness including the …
https://www.cambridge.org/core/journals/infection-control-and-hospital-epidemiology/article/implementation-of-a-multidisciplinary-48hour-antibiotic-timeout-in-a-pediatric-population/A3AB88CCAEA1ACBB73EC850A8F1B96D0
An ATO at 48 hours did not significantly decrease average antibiotic DOT in a pediatric population, regardless of methodology. Although LOS increased by 1 day, the ATO was not otherwise associated with increased mortality or 30-day readmissions. This study has several limitations. It was a single-center study.
https://www.researchgate.net/publication/11219038_Should_Antibiotics_be_Discontinued_at_48_Hours_for_Negative_Late-Onset_Sepsis_Evaluations_in_the_Neonatal_Intensive_Care_Unit
Usually, antibiotics are discontinued as soon as blood cultures are confirmed negative (48-72 hours), and if laboratory results and the evolution of the clinical signs allow to exclude an ...
https://onlinelibrary.wiley.com/doi/10.1111/apa.15202
The CPG was intended to support clinicians’ decision to discontinue antibiotics in infants ≥ 34+0 weeks of gestation when symptoms and laboratory findings after 36-48 hours made EOS a less likely diagnosis. The CPG consisted of a simple bundle with the following two main elements. First, we introduced an ASO for antibiotics after 48 hours.
https://pubmed.ncbi.nlm.nih.gov/31999863/
The intervention included an inter-hospital clinical practice guideline for discontinuing antibiotics after 36-48 hours if sepsis was no longer suspected and blood cultures were negative in neonates ≥ 34+0 weeks of gestation. Two units used procalcitonin in decision-making. We compared data 12-14 months before and after guideline implementation.
https://clinicaltrials.gov/ct2/show/NCT02906254
For the FUO group, antibiotics were stopped based on two procedures, irrespective of the neutrophil count or expected duration of neutropenia: - From 1st February 2014 to 30th November 2014, antibiotics were stopped when patients had been afebrile for more than 48 hours, as recommended by the ECIL-4 guidelines
https://content.findacode.com/documents/pqri/2008/PQRI%20Measure%2045_08_tag.pdf
within 48 hours of surgical end time OR specifying a course of antibiotic administration limited to that 48-hour period (eg, “to be given every 8 hours for three doses”) OR documentation that prophylactic antibiotic was discontinued within 48 hours of surgical end …
https://onlinelibrary.wiley.com/doi/epdf/10.1111/apa.15202
to discontinue antibiotics in infants ≥ 34+0 weeks of gestation when symptoms and laboratory findings after 36-48 hours made EOS a less likely diagnosis. The CPG consisted of a simple bundle with the following two main elements. First, we introduced an ASO for antibi-otics after 48 hours. Second, we recommended discontinuing antibi-
https://www.vumc.org/infection-prevention/discontinuation-isolation
The patient remains on contact isolation until the patient returns to his/her normal stooling pattern for minimum of 48 hours AND Patient is off of C. difficile -specific treatment Discharge or transfer from room so that all surfaces in room may be cleaned thoroughly
https://www.mpqhf.org/QIO/wp-content/uploads/2015/02/coremeasureposter.pdf
scip-1 & op-6 - prophylactic antibiotic preop timing scip-3 - prophylactic antibiotic discontinuation within 24 hours (48 hours for cv surgery) after surgery end time scip-4 - cardiac surgery patients with controlled postoperative blood glucose (< 180 mg/dl) within 18-24 hours after anesthesia end time scip-2 & op-7 - prophylactic antibiotic selection
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