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https://academic.oup.com/ofid/article/4/suppl_1/S272/4294658
Oct 04, 2017 · Background. An antibiotic time out (ATO) at 48–72 hours is a critical component of antimicrobial stewardship programs to improve judicious antibiotic use. It is a strategy to prompt clinicians to re-evaluate antibiotic appropriateness including the need for de-escalation and discontinuation.Cited by: 3
https://pubmed.ncbi.nlm.nih.gov/31999863/
The intervention included an inter-hospital clinical practice guideline for discontinuing antibiotics after 36-48 hours if sepsis was no longer suspected and blood cultures were negative in neonates ≥ 34+0 weeks of gestation. Two units used procalcitonin in decision-making. We compared data 12-14 months before and after guideline implementation.Cited by: 5
https://onlinelibrary.wiley.com/doi/10.1111/apa.15202
Jan 30, 2020 · A common CPG entitled ‘Active antibiotic discontinuation in near-term and term neonates’ was developed in 2016. The CPG was intended to support clinicians’ decision to discontinue antibiotics in infants ≥ 34+0 weeks of gestation when symptoms and laboratory findings after 36-48 hours made EOS a …Cited by: 5
https://dason.medicine.duke.edu/sites/dason.medicine.duke.edu/files/antibiotic_use_in_covid-19_faq_updated_8-28-2020.pdf
Aug 28, 2020 · Although empiric antibiotic therapy is often initiated upon presentation, particularly in those with severe COVID-19 pneumonia, consideration can be given to antibiotic discontinuation at 48 to 72 hours for patients with a positive test
https://www.cdc.gov/antibiotic-use/core-elements/hospital.html
A trial demonstrated that antibiotic timeouts at 48-72 hours of therapy improved the appropriateness of antibiotic selection, but did not reduce overall antibiotic use . Antibiotic timeouts are a useful supplemental intervention but should not be considered a substitute for prospective audit …
https://www.consultant360.com/story/five-days-antibiotics-adequate-community-acquired-pneumonia
Patients in the intervention group received a minimum of five days of antibiotics, and the antibiotic treatment was stopped at this point if the body temperature was 37.8°C or less for 48 hours and they had no more than one CAP-associated sign of clinical instability.
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