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https://pubmed.ncbi.nlm.nih.gov/32925658/
Higher MTX concentrations were observed in the AKI+ group. For cycle 1, all patients showing an MTX concentration >6 µM at 36 hours or >2 µM at 48 hours after infusion developed nephrotoxicity. The final pharmacokinetic model had 2 compartments and included the effect of age on clearance (CL) and of body weight on peripheral distribution volume.Author: Fanny Gallais, Lucie Oberic, Stanislas Faguer, Suzanne Tavitian, Thierry Lafont, Sabrina Marsili, Au...
https://pubmed.ncbi.nlm.nih.gov/16463431/
Objective: To study the bioavailability of a divided higher oral dose of methotrexate (MTX), in comparison to a single dose, in adult patients with rheumatoid arthritis (RA). Methods: A pharmacokinetic analysis was performed in 10 patients with RA taking a stable dose (25-35 mg weekly) of MTX. Separated by one week, a pharmacokinetic analysis was performed in each patient after an oral single ...Cited by: 70
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