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https://www.tandfonline.com/doi/abs/10.1517/17425247.4.5.547
Sep 16, 2016 · Azo compounds in colon-specific drug delivery. Azo compounds have the potential to act as drug carriers that facilitate the selective release of therapeutic agents to the colon, and also to effect the oral administration of those macromolecular drugs that require colon-specific drug delivery.Author: Marta Roldo, Eugen Barbu, James F Brown, David W Laight, John D Smart, John Tsibouklis
https://www.sciencedirect.com/science/article/pii/037851739290225Q
In order to develop a colon-specific drug delivery system, copolymers of 2-hydroxyethyl methacrylate and methyl methacrylate were prepared in the presence of bis(methacryloylamino)azobenzene. The conditions of polymerization were optimized to prevent crosslinking. Film coatings were prepared with the azo polymers.Author: G. Van den Mooter, C. Samyn, R. Kinget
https://www.researchgate.net/publication/5963378_Azo_compounds_in_colon-specific_drug_delivery
Azo compounds in colon-specific drug delivery. Azo compounds have the potential to act as drug carriers that facilitate the selective release of therapeutic agents to the colon, and also to effect the oral administration of those macromolecular drugs that require colon-specific drug delivery.
https://www.ncbi.nlm.nih.gov/pubmed/17425512
It is believed that flavin mediators present in the colon and azo-reductase enzymes released from colonic bacteria are responsible for the degradation of azo-aromatic compounds for site-specific delivery of the drug to the colon.Author: Anekant Jain, Yashwant Gupta, Sanjay Kumar Jain
https://www.sciencedirect.com/science/article/pii/S002235491550453X
Van den Mooter, C. Samyn, R. Kinget, Azo polymers for colon-specific drug delivery. II: Influence of the type of azo polymer on the degradation by intestinal microflora Int. J. Pharm. 97: (1993) 133-139 19.Author: G. Van Den Mooter, B. Maris, C. Samyn, P. Augustijns, R. Kinget
https://www.sciencedirect.com/science/article/pii/0169409X9190051D
The use of azo-reductase activity of colonic microflora has also been used to liberate 5-ASA from polymeric prodrugs and more recently to catalyze the partial degradation of hydrogels in the colon. These hydrogels may be useful in the delivery of peptides and proteins to the colon.Author: David R. Friend
https://www.sciencedirect.com/science/article/pii/0378517394900116
Furthermore, this would sug- gest that successful degradation of an azo poly- mer is not dependent upon the presence of a particular organism possessing a specific azo re- ductase in the colon and hence the principle of using azo polymers for colon specific drug deliv- ery is a valid approach, since low molecular weight electron mediators, such as NADPH, should be able to penetrate a swollen polymeric matrix.Author: Andrew W. Lloyd, Gary P. Martin, S.Hashem Soozandehfar
https://www.sciencedirect.com/science/article/pii/0168365995001840
Polymeric prodrugs of 5-aminosalicyclic acid in which the drug is coupled via an azo bond with a carrier polymer can release the parent drug when exposed to colon content. The amount of drug re- lease depends on the nature of the polymer and can approach that of low molecular weight pro-drugs.Author: Etienne Schacht, An Gevaert, El Refaie Kenawy, Koen Molly, Willy Verstraete, Peter Adriaensens, Robe...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215502/
Feb 07, 2010 · The polymers described as pH dependent in colon specific drug delivery are insoluble at low pH levels but become increasingly soluble as pH rises.21 Although a pH dependent polymer can protect a formulation in the stomach, and proximal small intestine, it may start to dissolve in the lower small intestine, and the site-specificity of formulations can be poor.22 The decline in pH from the end …Author: Anil K. Philip, Betty Philip
https://www.slideshare.net/GajananSanap/colon-targeted-drug-delivery-systems
Feb 27, 2016 · Azo polymeric new drug In which use of polymers as drug carriers for drug delivery to colon . Synthetic, naturally, sub-synthetic polymers used form colon targeted polymeric prodrug with azo linkage between polymer & drug moiety. The various azo …
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