Automated Drug Delivery System Focal Epilepsy

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An automated drug delivery system for focal epilepsy ...

    https://www.sciencedirect.com/science/article/pii/S0920121199001072
    Apr 03, 2000 · In summary, these experiments provide proof, in principle, of a closed loop, automated drug delivery system for the treatment of focal epilepsy. Development of a clinically useful system, however, will require attention to a number of issues such as drug stability at body temperature, risk of contamination from percutaneous re-filling...Author: Alan G Stein, Hans G Eder, David E Blum, Alexander Drachev, Robert S Fisher, Robert S Fisher

An automated drug delivery system for focal epilepsy ...

    https://europepmc.org/abstract/MED/10759298
    May 01, 2000 · Focal seizures were created in Sprague-Dawley rats using bicuculline, a GABA antagonist. Computerized detection of seizures was linked to a programmable infusion pump to deliver either diazepam (DZP) or pH-balanced vehicle (VEH) directly onto the seizure focus.Author: Alan G Stein, Hans G Eder, David E Blum, Alexander Drachev, Robert S Fisher, Robert S Fisher

An automated drug delivery system for focal epilepsy ...

    https://www.deepdyve.com/lp/elsevier/an-automated-drug-delivery-system-for-focal-epilepsy-bMhLTEYWTm
    Apr 03, 2000 · An automated drug delivery system for focal epilepsy The present experiments describe automated detection and focal therapy for seizures in the laboratory setting. Focal seizures were created in Sprague–Dawley rats using bicuculline, a GABA antagonist.

170966 Stanford Health Care

    https://stanfordhealthcare.org/publications/170/170966.html
    An automated drug delivery system for the treatment of intractable focal epilepsy. Notice: Users may be experiencing issues with displaying some pages on stanfordhealthcare.org. We are working closely with our technical teams to resolve the issue as quickly as possible. Thank you for your patience.

An IoT-based Drug Delivery System for Refractory Epilepsy

    https://www.researchgate.net/publication/331594661_An_IoT-based_Drug_Delivery_System_for_Refractory_Epilepsy
    automated drug delivery system for focal epilepsy,” Epilepsy Researc h, vol. 39, no. 2, pp. 103 – 114, 2000. ... (IoMT) based automated seizure detection and drug delivery system (DDS) for the ...

Evolution and Prospects for Intracranial Pharmacotherapy ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428620/
    The drug delivery minipump (Figure 6) consumes about 8 mAh energy, almost 10-times more than the rest of the device, and thus powering of the HNP needs a different engineering solution than what is adequate for the VNS, DBS or RNS. The complexity of the HNP as a seizure-preventing device mimics the evolutionary principle of implementing multiple (neural, endocrine and immune) control systems …Author: Nandor Ludvig, Geza Medveczky, Jacqueline A. French, Chad Carlson, Orrin Devinsky, Ruben I. Kuznieck...

Convection-enhanced delivery in the treatment of epilepsy ...

    https://link.springer.com/article/10.1016/j.nurt.2009.01.017
    Apr 01, 2009 · Convection-enhanced delivery (CED) is a novel drug-delivery technique that uses positive hydrostatic pressure to deliver a fluid containing a therapeutic s CED circumvents the blood-brain barrier and provides a wider, more homogenous distribution than bolus deposition (focal injection) or other diffusion-based delivery approaches.Author: Michael A. Rogawski

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