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https://www.sciencedirect.com/science/article/pii/S136759311000075X
Antibody-bound drug and released drug were distinguished by precipitating the mAb-bound drug with organic solvent and scintillation counting the supernatant containing the released drug. Both radiolabels quickly accumulated in the tumor, but the mAb peak was 1 …Author: Stephen C Alley, Nicole M Okeley, Peter D Senter
https://jhoonline.biomedcentral.com/articles/10.1186/1756-8722-5-70
Nov 09, 2012 · Therapeutic monoclonal antibody (TMA) based therapies for cancer have advanced significantly over the past two decades both in their molecular sophistication and clinical efficacy. Initial development efforts focused mainly on humanizing the antibody protein to overcome problems of immunogenicity and on expanding of the target antigen repertoire. In parallel to naked TMAs, antibody …Author: Michael A Firer, Gary Gellerman
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508879/
In view of the recognized importance of targeted drug delivery strategies for cancer therapy, we discuss the advantages of alternative drug carriers and where these should be applied, focusing on peptide-drug conjugates (PDCs), particularly those discovered through combinatorial peptide libraries.Author: Michael A Firer, Gary Gellerman
https://www.future-science.com/doi/10.4155/fdd-2020-0007
Mar 13, 2020 · Antibody–drug conjugate (ADC) technology has been the focus of intense interest as it is viewed as a sophisticated delivery system that combines the benefit of the highly specific tumor targeting of antibodies with the strong potency of a small molecule cytotoxic payload.Author: Justyna Mysliwy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944323/
Keywords: antibody drug conjugates, targeted cancer therapy, receptor mediated endocytosis, receptor overexpression, antibody bioengineering, advance linker, protein scaffold, Mylotarg, ... ADCs are an emerging class of targeted anticancer drug delivery agent that confer selective and sustained cytotoxic drug delivery to tumors .Author: Samaresh Sau, Hashem O. Alsaab, Hashem O. Alsaab, Sushil Kumar Kashaw, Sushil Kumar Kashaw, Katyayan...
https://www.sciencedaily.com/releases/2020/03/200309152051.htm
Mar 09, 2020 · Protecting DNA origami for anti-cancer drug delivery Date: March 9, 2020 ... More commonly known by the brand name Herceptin, trastuzumab is an antibody …
https://jhoonline.biomedcentral.com/track/pdf/10.1186/1756-8722-5-70
REVIEW Open Access Targeted drug delivery for cancer therapy: the other side of antibodies Michael A Firer1* and Gary Gellerman2 Abstract Therapeutic monoclonal antibody (TMA) based therapies for cancer have advanced significantly over the past twoAuthor: Michael A Firer, Gary Gellerman
https://www.annualreviews.org/doi/abs/10.1146/annurev-med-050311-201823
An antibody-drug conjugate (ADC) provides the possibility of selectively ablating cancer cells by combining the specificity of a monoclonal antibody (mAb) for a target antigen with the delivery of a highly potent cytotoxic agent. ADC target antigens are typically highly expressed on the surface of cancer cells compared to normal cells. The tumor target, the cytotoxic agent, and the manner in ...Author: Eric L. Sievers, Peter D. Senter
https://www.adcreview.com/the-review/antibody-drug-conjugates/targeting-cancer-with-antibody-drug-conjugates/
Apr 17, 2019 · In parallel to naked monoclonal antibodies, antibody-drug conjugates (ADCs) have been developed to target the delivery of highly potent cytotoxic anti-cancer drugs with the aim of bypassing the morbidity common to conventional chemotherapy. This and ongoing research has made a new generation of ADCs possible.
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