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https://www.researchgate.net/publication/20963749_Animal_models_for_intranasal_drug_delivery_studies_A_review_article
A topical overview is given for following animal models which are all involved in intranasal drug or vaccine delivery research; dog, guinea pig, hamster, mouse, rabbit (in vivo and in situ), rat ...Author: Sveinbjorn Gizurarson
https://www.celerion.com/wp-content/uploads/2015/05/Celerion_050515_TIDES_Intranasal-Drug-Delivery.pdf
Intranasal Drug Delivery: Drug Development Considerations Bruce H Morimoto, PhD ... Adapted from: Gizurarson S: Animal models for intranasal drug delivery studies. A . 17 review article.Acta Pharm Nord . 2(2), 105 -122 (1990) ... from animal safety studies used to inform a starting clinical dose Allometric scaling is one method to compare doses ...File Size: 1MB
https://www.sciencedirect.com/science/article/pii/S0361923018303678
After this introductory part various in vitro, ex vivo and in vivo models for investigation of intranasal drug delivery will be presented based on the latest literature of the field. Then some studies which evaluate the intranasal penetration of drugs for different CNS indications will be shown.Author: Franciska Erdő, Luca Anna Bors, Dániel Farkas, Ágnes Bajza, Sveinbjörn Gizurarson
https://www.researchgate.net/profile/Sveinbjorn_Gizurarson/publication/20963749_Animal_models_for_intranasal_drug_delivery_studies_A_review_article/links/573ed7ba08ae298602e8de26/Animal-models-for-intranasal-drug-delivery-studies-A-review-article.pdf
http://europepmc.org/abstract/MED/2191690
Jan 01, 1990 · A topical overview is given for following animal models which are all involved in intranasal drug or vaccine delivery research; dog, guinea pig, hamster, mouse, rabbit (in vivo and in situ), rat (in vivo, in vivo surgical and in situ) and sheep. In the selection of an animal model, both advantages and disadvantages must be considered.Author: Gizurarson S
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2604883/
Dec 10, 2008 · Intranasal insulin-like growth factor-I, deferoxamine, and erythropoietin have been shown to protect the brain against stroke in animal models. Intranasal delivery has been used to target the neuroprotective peptide NAP to the brain to treat neurodegeneration.Author: Leah R Hanson, William H Frey, William H Frey
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653240/
Apr 08, 2013 · Intranasal delivery of drugs in animal models allows for initial evaluation of pharmacokinetic distribution and efficacy. With mice, it is possible to administer drugs to awake (non-anesthetized) animals on a regular basis using a specialized intranasal grip. ... Intranasal administration also results in high concentrations of drug reaching the ...Author: Leah R. Hanson, Jared M. Fine, Aleta L. Svitak, Katherine A. Faltesek
https://drug-dev.com/nasal-delivery-a-promising-route-of-drug-delivery-to-the-brain-scientific-considerations-2/
Because the ultimate goal of performing studies in animal models is to collect data and parameters that can be translated to human studies, there still exists a gap in establishing meaningful correlations. ... Gizurarson S. Anatomical and histological factors affecting intranasal drug and vaccine delivery. Curr Drug Deliv. 2012;9:566-582.
https://www.sciencedirect.com/science/article/pii/S0304394019306706
Intranasal (IN) delivery of insulin has been shown to provide benefits to both animal models of neurodegenerative disease and humans in clinical trials. Intranasal delivery provides a means of bypassing the blood-brain barrier as drugs travel directly along the olfactory and trigeminal nerves to target the brain . This process can be ...Author: Jared M. Fine, Benjamin M. Stroebel, Katherine A. Faltesek, Kaoru Terai, Lucas Haase, Kristin E. Knu...
https://www.nature.com/articles/nb.1866
Jun 07, 2011 · Intranasal delivery to the brain. To date, the majority of studies investigating this delivery mechanism have looked only at animal models 11, but both short- and …Author: Robert I Henkin
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