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https://www.sciencedirect.com/science/article/pii/S0920121199001072
Apr 03, 2000 · In summary, these experiments provide proof, in principle, of a closed loop, automated drug delivery system for the treatment of focal epilepsy. Development of a clinically useful system, however, will require attention to a number of issues such as drug stability at body temperature, risk of contamination from percutaneous re-filling...Author: Alan G Stein, Hans G Eder, David E Blum, Alexander Drachev, Robert S Fisher, Robert S Fisher
https://europepmc.org/abstract/MED/10759298
May 01, 2000 · The present experiments describe automated detection and focal therapy for seizures in the laboratory setting. Focal seizures were created in Sprague-Dawley rats using bicuculline, a GABA antagonist. Computerized detection of seizures was linked to a programmable infusion pump to deliver either diazepam (DZP) or pH-balanced vehicle (VEH) directly onto the seizure focus.Author: Alan G Stein, Hans G Eder, David E Blum, Alexander Drachev, Robert S Fisher, Robert S Fisher
https://www.deepdyve.com/lp/elsevier/an-automated-drug-delivery-system-for-focal-epilepsy-bMhLTEYWTm
Apr 03, 2000 · An automated drug delivery system for focal epilepsy The present experiments describe automated detection and focal therapy for seizures in the laboratory setting. Focal seizures were created in Sprague–Dawley rats using bicuculline, a GABA antagonist.
https://www.researchgate.net/publication/331594661_An_IoT-based_Drug_Delivery_System_for_Refractory_Epilepsy
In the current extended paper, an automated unified system is proposed in the IoMT platform, which performs both seizure detection and drug injection simultaneously to disrupt and control seizure ...
https://link.springer.com/article/10.1016/j.nurt.2009.01.017
Apr 01, 2009 · Convection-enhanced delivery (CED) is a novel drug-delivery technique that uses positive hydrostatic pressure to deliver a fluid containing a therapeutic s CED circumvents the blood-brain barrier and provides a wider, more homogenous distribution than bolus deposition (focal injection) or other diffusion-based delivery approaches.Author: Michael A. Rogawski
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639564/
The LED will need to be implanted within the vicinity of the seizure focus, and additional devices will be required to complete a complex integrated system—including a battery source and amplifier for the LED, electrodes and seizure-detection system to sense the seizures, and a long-term drug-administration system for the caged-GABA.
https://www.aesnet.org/sites/default/files/file_attach/epcu-13-2-95%20Basic%20Commentary%20Wong.pdf
integrated system—including a battery source and amplifier for the LED, electrodes and seizure-detection system to sense the seizures, and a long-term drug-administration system for the caged-GABA. LEDs can be integrated within flexible two-dimensional electrode arrays or …
https://www.epilepsy.com/article/2020/3/concerns-about-covid-19-coronavirus-and-epilepsy
Marie has a rare chromosomal disorder called Ring 14 syndrome. The disorder and it’s underlying conditions like a compromised pulmonary system, intractable epilepsy, and intellectual disabilities, put her at high risk for a severe case of COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904395/
The currently proposed strategies for intervention in implantable antiepileptic devices are electrical stimulation, magnetic stimulation, 44 localized drug delivery, 51 and focal cooling. 71 Electrical stimulation is further divided into continuous, responsive and controlling paradigms. All three of the electrical devices currently in use or in clinical trials use periodic pulse trains: the VNS and Medtronic …Author: William C Stacey, Brian Litt
https://www.medscape.org/viewarticle/838058
Oct 23, 2019 · The use of devices in the treatment of epilepsy is an emerging therapy for those patients whose seizures are not controlled by medications. This article will discuss current treatment options with devices for vagus nerve stimulation, deep brain stimulation and responsive neurostimulation.
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