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https://www.ncbi.nlm.nih.gov/pubmed/12877636
As a result of strong lipophilic properties, encapsulation in liposomes or binding to lipid complexes led to the development of lipid formulations in an attempt to increase both efficacy and safety. Three lipid formulations of amphotericin B are commercially available: a liposomal preparation, a lipid complex and a colloidal dispersion.Author: Raoul Herbrecht, Shanti Natarajan-Amé, Yasmine Nivoix, Valérie Letscher-Bru
https://www.ncbi.nlm.nih.gov/pubmed/11801578
Overview of the lipid formulations of amphotericin B. ... Lipid formulations offer a better therapeutic index by circumscribing amphotericin B toxicity. Three lipid formulations are available in most countries: AmBisome, the only true liposome; Abelcet, with a ribbon-like structure; and Amphocil/Amphotec, composed of disc-like structures. All ...Author: Bertrand Dupont
https://www.uptodate.com/contents/pharmacology-of-amphotericin-b
INTRODUCTION. Amphotericin B is a polyene antifungal agent with activity in vitro against a wide variety of fungal pathogens [].Amphotericin B exerts its antifungal effect by disruption of fungal cell wall synthesis because of its ability to bind to sterols, primarily ergosterol, which leads to the formation of pores that allow leakage of cellular components.
https://academic.oup.com/mmy/article/54/3/223/2579231
Jan 14, 2016 · Abstract. Given the clinical success of commercial amphotericin B lipid products, investigators have begun making generic formulations of liposomal amphotericin B. Generic medicines are an attractive approach to help decrease the cost and accessibility to healthcare, provided that appropriate studies are performed to ensure bioequivalence with the parent product.Author: Jill P Adler-Moore, Jean-Pierre Gangneux, Peter G Pappas
https://www.sciencedirect.com/science/article/pii/S0022354916326119
Amphotericin B Formulations and Drug Targeting. ... J. BolardRelease of amphotericin B from delivery systems and its action against fungal and mammalian cells. J Drug Target, 4 (1997), pp. 311-319. ... S.L. CroftComparison of the activities of three amphotericin B lipid formulations against experimental visceral and cutaneous leishmaniasis.Author: J.J. Torrado, R. Espada, M.P. Ballesteros, S. Torrado-Santiago
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