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https://en.wikipedia.org/wiki/Osmotic_controlled-release_oral_delivery_system
The osmotic-controlled release oral delivery system (OROS) is an advanced controlled release oral drug delivery system in the form of a rigid tablet with a semi-permeable outer membrane and one or more small laser drilled holes in it. As the tablet passes through the body, water is absorbed through the semipermeable membrane via osmosis, and the resulting osmotic pressure is used to push the ...
https://www.dragonroids.com/connetics-alza-drug-delivery/
ALZA Corporation is a research-based pharmaceutical company with leading drug delivery technologies. The company applies its delivery technologies to develop pharmaceutical products with enhanced therapeutic value for its own portfolio and for many of the world’s leading pharmaceutical companies.
https://patents.google.com/patent/US3854480A/en
Drug-delivery system for releasing drug at a controlled rate for a prolonged period of time is formed from a solid inner matrix material having solid particles of drug dispersed therethrough. Surrounding the inner matrix is an outer polymeric membrane, insoluble in body fluids. Both the inner matrix material and the outer polymeric membrane are permeable to passage of the drug by diffusion but ...Author: Wouter De Graaff, Raymond Zeeman
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215502/
Feb 07, 2010 · a. pH Sensitive Polymer Coated Drug Delivery to the Colon . In the stomach, pH ranges between 1 and 2 during fasting but increases after eating.18 The pH is about 6.5 in the proximal small intestine, and about 7.5 in the distal small intestine.19 From the ileum to the colon, pH declines significantly. It is about 6.4 in the cecum.Author: Anil K. Philip, Betty Philip
https://www.marketwatch.com/press-release/transmucosal-drug-delivery-market-2020-regional-and-country-level-analysis-by-manufacturers-alza-corporation-acrux-limited-antares-pharma-and-3m-pharmaceuticals-2020-03-26?mod=mw_quote_news
Mar 26, 2020 · Press Release Transmucosal Drug Delivery Market 2020 Regional and Country-level analysis by Manufacturers: ALZA Corporation, Acrux Limited, Antares Pharma and 3M Pharmaceuticals
https://www.contractpharma.com/issues/2002-04/view_features/drug-delivery
In March of last year, the second largest drug delivery company, Alza, was acquired by Johnson &Johnson. It's true that Alza had several pharmaceutical products on the market, as well as in the pipeline, that made it attractive to J&J, but its delivery business was comparable to Elan's.
http://ijpsr.com/bft-article/a-review-on-osmotic-pump-drug-delivery-system/?view=fulltext
A REVIEW ON OSMOTIC PUMP DRUG DELIVERY SYSTEM HTML Full Text. A REVIEW ON OSMOTIC PUMP DRUG DELIVERY SYSTEM. M. Mathur * and R. Mishra. Department of Pharmaceutics, Institute of Pharmacy, Nirma University, Sarkhej-Gandhinagar Highway, Ahmadabad- 382 481, Gujarat, India
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769721/
In all three examples of drug delivery from DUROS devices, start-up of the devices occurs rapidly, with drug delivery reaching steady state within the first few days of operation. The start-up profiles are smooth and do not contain the very high peaks typically associated with subcutaneously injected proteins.Author: Catherine M. Rohloff, Thomas R. Alessi, Bing Yang, Janice Dahms, John P. Carr, Scott D. Lautenbach
https://www.alzet.com/company/
They were initially developed for use during internal company research, and for use by some of ALZA’s collaborators working at academic institutions. It did not take long for the word to spread about the existence of a novel drug delivery system that allowed for continuous administration of test agents into laboratory animals.
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