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https://www.ncbi.nlm.nih.gov/pubmed/12149954/
Dried sodium alginate beads reswell, creating a diffusion barrier decreasing the migration of small molecules (e.g., drugs). The ability of alginate to form two types of gel dependent on pH, i.e., an acid gel and an ionotropic gel, gives the polymer unique properties compared to neutral macromolecules.Author: Hanne Hjorth Tønnesen, Jan Karlsen
https://www.sciencedirect.com/science/article/pii/S0378517302000546
In this paper the floating drug delivery system employs calcium carbonate (CaCO 3 ) or sodium bicarbonate (NaHCO 3 ) as a gas-forming agent dispersed in an alginate matrix. Alginate is a polysaccharide which contains varying amounts of 1,4′-linked β-d …Author: B. Y. Choi, Hyun Jin Park, S. J. Hwang, J. B. Park
https://www.tandfonline.com/doi/pdf/10.1081/DDC-120003853
range of applications. The conventional use of alginate as an excipient in drug products generally depends on the thickening, gel-forming, and stabilizing proper-ties. A need for prolonged and better control of drug administration has increased the demand for tailor-made polymers. Hydrocolloids like alginate can play a
https://www.pharmatutor.org/articles/drug-delivery-using-alginate-chitosan-beads
Alginate and chitosan are commonly used polymers in modifying the drug release. These two polymers can be used together or separately to form drug loaded modified release beads. The ionotropic gelation method and a slight modification in various ways are used to prepare these beads of different characteristics.
https://pharmahub.org/resources/534/download/Alginate_Bead_Experiment.pdf
alginate our hydrogels, the chains are connected by calcium ions. There are “spaces” between crosslinks (designated by the symbol ζ in Figure 4) that allow for drug diffusion. Smaller molecules can diffuse through these spaces more easily, resulting in increased drug delivery rates. Figure 3. Solute diffusing through a spherical hydrogel. Figure 4.File Size: 165KB
https://pubs.acs.org/doi/abs/10.1021/acsami.6b10914
Carbon-dot-coated novel alginate beads (CA-CD) exhibiting superior stability was successfully used as smart drug delivery vehicle. Garlic extract (GE), which contains allicin, was taken as model drug system to demonstrate the phenomena.Author: Sristi Majumdar, Gargee Krishnatreya, Neelam Gogoi, Debajit Thakur, Devasish Chowdhury
https://www.sciencedirect.com/science/article/pii/S0141813019364980
Hence, alginate microcapsules have widely been applied in the drug delivery system based on the diffusion pathway, where the drug diffuses out through the swell able polymer network , . In the polymer micro matrix system, the drug release mechanism is mainly based on the combination of diffusion and degradation of polymer matrix.Author: Nguyen Thi Thanh Uyen, Zuratul Ain Abdul Hamid, Nguyen Xuan Thanh Tram, Nurazreena Ahmad
https://www.researchgate.net/publication/272896433_Drug_delivery_using_alginate_and_chitosan_beads_An_Overview
Alginate and chitosan are commonly used polymers in modifying the drug release. These two polymers can be used together or separately to form drug loaded modified release beads. The ionotropic gelation method and a slight modification in various ways are used to prepare these beads of different characteristics.
https://pubag.nal.usda.gov/catalog/6822640
Alginate-poloxamer beads for clotrimazole delivery: Molecular interactions, mechanical properties, and anticandidal activity Author: Khlibsuwan, Rapee, Khunkitti, Watcharee, Pongjanyakul, Thaned Source: International journal of biological macromolecules 2020 v.148 pp. 1061-1071 ISSN: 0141-8130 Subject:
http://www.imedpub.com/articles/formulation-development-and-characterization-of-alginate-beads-of-ranitidine-hydrochloride.pdf
The use of sodium alginate and combinations of sodium alginate and pectin were used to study the effect on the sustaining property of the formed beads. It was found that sodium alginate was not sufficient to sustain the drug release at gastric pH. Instead of it, appropriate combination of alginate and pectin could provide the sustain release of drug. The results show that these beads can entrap even aAuthor: Navneet Kumar Verma, Shivendra Pratap Singh, Praveen Kumar Rai, Reena Singh, Ashok Kumar Tripathi
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