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https://www.researchgate.net/publication/11813271_Airways_delivery_of_rifampicin_microparticles_for_the_treatment_of_tuberculosis
Airways delivery of rifampicin microparticles for the treatment of tuberculosis Article (PDF Available) in Journal of Antimicrobial Chemotherapy 48(3):431-4 · September 2001 with 45 Reads
https://academic.oup.com/jac/article/48/3/431/736083
Sep 01, 2001 · Rifampicin-loaded microspheres were administered directly into the lungs, potentially circumventing the toxicity (notably hepatitis) resulting from large oral doses (600 mg daily over 6 months). Delayed release of rifampicin from R-PLGA was contrasted with the immediate release from rifampicin by delivery of microparticles 24 h before infection.Author: Sandra Suarez, Patrick O'Hara, Masha Kazantseva, Christian E. Newcomer, Roy Hopfer, David N. McMurra...
https://www.ncbi.nlm.nih.gov/pubmed/11533012
Airways delivery of rifampicin microparticles for the treatment of tuberculosis. Suarez S(1), O'Hara P, Kazantseva M, Newcomer CE, Hopfer R, McMurray DN, Hickey AJ. Author information: (1)School of Pharmacy, and Department of Pathology and Laboratory Animal Medicine, University of North Carolina at Chapel Hill, 27599, USA.Author: Sandra Suarez, Patrick O'Hara, Masha Kazantseva, Christian E. Newcomer, Roy Hopfer, David N. McMurra...
https://www.rti.org/publication/airways-delivery-rifampicin-microparticles-treatment-tuberculosis
Apr 20, 2017 · Airways delivery of rifampicin microparticles for the treatment of tuberculosis; ... Airways delivery of rifampicin microparticles for the treatment of tuberculosis. Journal of Antimicrobial Chemotherapy, 48(3), 431-434.Author: Sandra Suarez, Patrick O'Hara, Masha Kazantseva, Christian E. Newcomer, Roy Hopfer, David N. McMurra...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255431/
Tuberculosis is an ancient scourge[] and a global health problem causing an increase in mortality and morbidity[].The synergistic pathology of co-infection with the human immune deficiency virus has fuelled the disease, as well as the continued resistance of Mycobacterium tuberculosis strains to multiple antibiotics is the cause for physician's armamentarium for treating and preventing ...
https://academic.oup.com/jac/article/58/5/980/742629
Sep 13, 2006 · For comparison with treatment with once a week microsphere suspensions, additional experiments were performed for the last 20 (20-RIF) and 10 days (10-RIF) of a 28 day TB infection cycle which involved the daily administration of suspensions of micronized rifampicin, as well as saline to control animals (untreated controls, 10-SAL and 20-SAL).Author: L Garcia-Contreras, V Sethuraman, M Kazantseva, V Godfrey, Anthony Hickey
https://www.ondrugdelivery.com/pulmonary-delivery-antimicrobial-peptides/
Nanoformulation concepts used for pulmonary delivery of various small-molecule TB drugs such as rifampicin may be possible to translate to peptide delivery, although this has not been tested yet. One of the most studied concepts is liposomes, which are able to hold active substances inside as well as in/on the surface of the liposomes.
https://www.researchgate.net/publication/6820418_Evaluation_of_dosing_regimen_of_respirable_rifampicin_biodegradable_microspheres_in_the_treatment_of_tuberculosis_in_the_guinea_pig
Evaluation of dosing regimen of respirable rifampicin biodegradable microspheres in the treatment of tuberculosis in the guinea pig. ... Airways delivery of.
https://www.sciencedirect.com/science/article/pii/S0032591014004070
It can be concluded that prepared spray dried poly-ɛ-caprolactone microparticles of isoniazid provided the advantage of controlled release characteristics deep inside the lung where tubercular bacilli resides and due to inhaled characteristics suitable for pulmonary drug delivery it may help in improving treatment of tuberculosis through ...Author: Rajesh Parikh, Sonali Dalwadi
https://link.springer.com/article/10.1007%2Fs11095-009-9894-2
Apr 30, 2009 · To formulate rifampicin, an anti-tuberculosis antibiotic, for aerosol delivery in a dry powder ‘porous nanoparticle-aggregate particle’ (PNAP) form suited for shelf stability, effective dispersibility and extended release with local lung and systemic drug delivery. Rifampicin was encapsulated in PLGA nanoparticles by a solvent evaporation process, spray dried into PNAPs …Author: Jean C. Sung, Danielle J. Padilla, Lucila Garcia-Contreras, Jarod L. VerBerkmoes, David Durbin, Char...
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