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http://www.pharmtech.com/four-challenges-pulmonary-drug-delivery
Sep 01, 2017 · Pulmonary drug delivery is receiving increased attention as a non-invasive means for local treatment of a wide range of major lung diseases; this route of administration, however, poses additional challenges for medicinal and formulation chemists.
https://clinicalgate.com/pulmonary-drug-delivery/
• Pulmonary delivery may be used for drugs having local or systemic activity. • Effective drug delivery to the lungs is dependent on the formulation, the delivery device and the patient. • The structure of the airways is effective in preventing entry of materials, including therapeutic aerosols.
https://www.pharmatutor.org/articles/pulmonary-drug-delivery-a-review
The delivery of the drug through the respiratory tract is called pulmonary drug delivery. In case of brochodialating drugs, this is advantageous as drug will deliver directly to region where its action is required so that the drug effect will be faster and low dose of drug can be administered through this delivery system and so the side effects can be decreased.
https://innovareacademics.in/journal/ijap/Vol2Issue4/126.pdf
In this article, we summarize the rationale behind the advances of pulmonary drug delivery system. Pulmonary drug delivery is an important research area which impacts the treatment of illnesses including asthma, chronic obstructive pulmonary disease and various other diseases.
https://www.sciencedirect.com/science/article/pii/S0169409X14002300
Liposomal, polymeric and nanoparticle formulations of inhaled antibiotics are advanced drug delivery systems designed for the purposes of targeting drug delivery, sustaining drug release and enhancing the anti-microbial activities of antibiotics in the lungs.Author: Qi (Tony) Zhou, Sharon Shui Yee Leung, Patricia Tang, Thaigarajan Parumasivam, Zhi Hui Loh, Hak-Kim ...
https://www.slideshare.net/sagarsavale1/pulmonary-drug-delivery-system-pdds
Jun 19, 2016 · Pulmonary drug delivery is primarily used to treat conditions of the airways, delivering locally acting drugs directly to their site of action. Delivery of drugs directly to their site of action reduces the dose needed to produce a pharmacological effect. ...
https://www.researchgate.net/publication/7812539_Pulmonary_Drug_Delivery_Systems_Recent_Developments_and_Prospects
Intratracheal administration is commonly used as a first approach in lung drug delivery in vivo. To convey a sufficient dose of drug to the lungs, suitable drug carriers are required.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013600/
Apr 08, 2014 · Liposomes are an attractive drug delivery system, especially for pulmonary applications, as it is prepared primarily from phospholipids, which are inherent in lungs. They are prepared using lung surfactants, phospholipids, cholesterol, etc. Liposomes possess sustained release properties, which enable the maximum drug effect over a prolonged time period.Author: Mukta Paranjpe, Christel C. Müller-Goymann
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1884307/
Apr 19, 2002 · Pulmonary drug delivery offers several advantages as a route of administration for the treatment of systemic diseases compared with intravenous, oral, buccal, transdermal, vaginal, nasal or ocular administration. The advantages of pulmonary administration are listed in Table 1 [20–23]. Until recently, aerosol drug delivery has been limited to topical therapy for the lung and nose.Author: N. R. Labiris, M. B. Dolovich
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