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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1884307/
Apr 19, 2002 · Rees et al. [ 10] reported the varying clinical effect of 250 µg of aerosolized terbutaline from a metered dose inhaler (MDI) given as three different particle sizes: <5 µm, 5–10 µm and 10–15 µm. In asthmatics, the greatest increase in forced expiratory volume in 1 s (FEV 1 ),...Author: N. R. Labiris, M. B. Dolovich
https://www.aarc.org/wp-content/uploads/2015/04/aerosol_guide_rt.pdf
A measure that quantifies a polydisperse aerosol is the mass median diameter (MMD). This measure determines the particle size (in µm) above and below which 50% of the mass of the particles is con- …
https://www.sciencedirect.com/science/article/pii/S0753332218350066
Today, among the available delivery options, mostly DPIs consists of fine powder drug (particle size <5 μm) blended with larger carrier particles generally lactose. Presence of lactose helps to improve powder flow before the aerosolized delivery of the drug formulation.Author: Akshay Chandel, Amit K. Goyal, Goutam Ghosh, Goutam Rath
https://www.ncbi.nlm.nih.gov/pubmed/10894453
Influence of inspiratory flow rate, particle size, and airway caliber on aerosolized drug delivery to the lung. Dolovich MA(1). Author information: (1)Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada. [email protected]: Dolovich Ma
http://www.nasoneb.com/pdfs/NasoNebparticlesizeairflow.pdf
For nasal deposition, the optimal droplet or particle size should be, on the whole, substantially larger than the respirable fragment size, or larger than 5 microns 15. The NasoNeb Nasal Nebulizer delivers a …
https://ccforum.biomedcentral.com/articles/10.1186/s13054-016-1448-5
Oct 07, 2016 · Significance—For aerosolized drug delivery, larger size artificial airways are better. Heat and humidity of the circuit In mechanically ventilated patients, a temperature of 34–41 °C (average 37 °C) and relative humidity of 95–100 % are required to prevent heat loss [ 100 ].Author: Jayesh Dhanani, Jayesh Dhanani, John F. Fraser, Hak-Kim Chan, Jordi Rello, Jeremy Cohen, Jeremy Cohe...
https://www.sciencedirect.com/science/article/pii/S0140673610609269
The major factors that affect the efficiency of drug delivery during mechanical ventilation include: the position of the patient, the aerosol generator and its configuration in the ventilator circuit, aerosol particle size, synchronisation of aerosol generation with inspiratory airflow from the ventilator, conditions in the ventilator circuit ...Author: Myrna B Dolovich, Rajiv Dhand
https://www.pharmamanufacturing.com/assets/Media/MediaManager/Microfluidics_achieve-optimal-part-size_inhalation-therapy.pdf
suspended drugs and the goal is to deliver aerosol droplets with a mean particle size of 3.0 µm, the component drug suspended inside the liquid droplets must have a particle size smaller than 3.0 µm. Otherwise the droplet would not be able to carry the drug andFile Size: 123KB
https://www.liebertpub.com/doi/abs/10.1089/jam.1991.4.223
Mar 19, 2009 · Some of the parameters that affect deposition are discussed (e.g., particle size, breathing pattern, airway caliber). It is suggested that these parameters be controlled or measured when characterizing new aerosol delivery systems for clinical investigations.Author: William D. Bennett
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