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https://www.ncbi.nlm.nih.gov/pubmed/3967508
To study the effects of respiratory failure and mechanical ventilation on aerosol delivery to the lungs, we performed nuclear scans after aerosolization of 5 to 9 mCi of Tc-99m diethylenetriamine pentaacetic acid in seven stable, intubated, and mechanically ventilated patients.Author: Neil Macintyre, Robert Silver, Charles Miller, Frank Schuler, R. Coleman
https://www.ncbi.nlm.nih.gov/pubmed/23614495
INTRODUCTION: Approximately 20 million patients are intubated in the USA each year, primarily for the administration of drugs. While the vast majority of these medications are administered as gas or instilled, there is a growing practice of aerosol administration to intubated patients, often associated with mechanical ventilation.Author: James Fink, Arzu Ari
https://www.rtmagazine.com/products-treatment/monitoring-treatment/therapy-devices/aerosol-delivery-mechanical-ventilation/
Jul 02, 2019 · An international survey in 2013 revealed that more than 95% of intensivists use aerosol therapy during mechanical ventilation.[1] This method of drug delivery differs in several ways from inhaled drug delivery administered to spontaneously breathing patients.
https://www.researchgate.net/publication/236327001_Aerosol_delivery_to_intubated_patients
There are some informative reviews available covering the history and methodology associated with aerosol delivery to intubated and ventilated adult patients [9], and aerosol delivery in the ...
https://ccforum.biomedcentral.com/articles/10.1186/s13054-017-1844-5
Oct 21, 2017 · This systematic review aimed to assess inhaled drug delivery in mechanically ventilated patients or in animal models. Whole lung and regional deposition and the impact of the ventilator circuit, the artificial airways and the administration technique for aerosol delivery were analyzed. In vivo studies assessing lung deposition during invasive mechanical ventilation were selected based on a ...Author: Jonathan Dugernier, Stephan Ehrmann, Stephan Ehrmann, Thierry Sottiaux, Jean Roeseler, Xavier Witteb...
https://www.tandfonline.com/doi/abs/10.1517/17425247.2013.790362
May 20, 2015 · Introduction: Approximately 20 million patients are intubated in the USA each year, primarily for the administration of drugs. While the vast majority of these medications are administered as gas or instilled, there is a growing practice of aerosol administration to intubated patients, often associated with mechanical ventilation.Author: James Fink, Arzu Ari
http://rc.rcjournal.com/content/57/7/1066
Jul 01, 2012 · BACKGROUND: Previous research reporting factors influencing aerosol delivery in intubated patients has been largely focused on the endotracheal tube (ETT) during mechanical ventilation, with little comparative analysis of effect of types of artificial airways and their interfaces on aerosol delivery during spontaneous breathing. The purpose of this study was to compare aerosol …
https://www.atsjournals.org/doi/full/10.1164/ajrccm.156.1.9610025
Jul 01, 1997 · In mechanically ventilated patients, the efficiency of aerosol delivery to the lower respiratory tract depends on several factors that are not concerns in ambulatory patients ().Important determinants of aerosol deposition in ventilator-supported patients include the delivery system, particle size, characteristics of the ventilator circuit, ventilator mode, and patient-related factors.Author: Rajiv Dhand, Martin J. Tobin
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