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https://www.cell.com/molecular-therapy-family/molecular-therapy/pdf/S1525-0016(16)39875-6.pdf
showed that aerosol delivery of CTMP inhibited proteins important for Akt1 signals, cell cycle and tumor metastasis. However, no study has investigated the effect of long-term repeated effect of CTMP on tumor progression. In this study, we addressed this question by studying the effects of lentivirus-based CTMP in the lungs of K-rasLA1 mice.
https://www.atsjournals.org/doi/pdf/10.1164/rccm.200810-1553OC
that repeated aerosol delivery of lentivirus-CTMP significantly suppresses tumor growth at different stages of development in the lungs of K-rasLA1 mice through altering Akt-related signals. Our results support the notion that lentivirus may act as an effective carrier, and that repeated aerosol delivery of CTMP
https://www.ncbi.nlm.nih.gov/pubmed/17960162
Aerosol delivery of CTMP inhibited proteins important for Akt1 signals, cell cycle and tumor metastasis in lungs of K-ras null mice. Together, our results suggest that lentivirus-mediated aerosol delivery of CTMP may be compatible with noninvasive in vivo gene therapy.Author: S-K Hwang, J-T Kwon, S-J Park, S-H Chang, E-S Lee, Y-S Chung, GR Beck Jr, KH Lee, L Piao, J Park, My...
https://www.nature.com/articles/3303042
Oct 25, 2007 · Aerosol delivery of CTMP inhibited proteins important for Akt1 signals, cell cycle and tumor metastasis in lungs of K-ras null mice. Together, our results suggest that lentivirus-mediated aerosol ...Author: S-K Hwang, J-T Kwon, S-J Park, S-H Chang, E-S Lee, Y-S Chung, GR Beck Jr, KH Lee, L Piao, J Park, My...
https://www.atsjournals.org/doi/abs/10.1164/rccm.200810-1553OC
Jun 15, 2009 · Recent advances in aerosol-mediated gene delivery have provided the possibility of an alternative for the safe and effective treatment of lung cancer.Objectives: To investigate the repeated effect of carboxyl-terminal modulator protein (CTMP) on multistage lung tumorigenesis.Author: Soon-Kyung Hwang, Hwang-Tae Lim, Arash Minai-Tehrani, Eun-Sun Lee, Jongmin Park, Seung Bum Park, Geo...
https://www.worldhealth.net/news/new_method_for_delivering_gene_therapy_d/
"Our results demonstrated that lentivirus-mediated CTMP overexpression suppressed Akt activity and inhibited tumor progression," writes Dr. Cho. "Repeated aerosol gene delivery may provide an effective noninvasive model of gene delivery and understanding the role of CTMP in the multistage lung tumorigenesis may be essential in developing ...
https://www.researchgate.net/publication/5886016_Lentivirus-mediated_carboxyl-terminal_modulator_protein_gene_transfection_via_aerosol_in_lungs_of_K-ras_null_mice
Lentivirus-mediated carboxyl-terminal modulator protein gene transfection via aerosol in lungs of K-ras null mice ... mediated aerosol delivery of CTMP may be compatible with noninvasive in vivo ...
https://www.sciencedaily.com/releases/2009/06/090608125112.htm
Jun 10, 2009 · Vaporized Viral Vector Shows Promise In Anti-cancer Gene Therapy ... "Aerosol delivery targets the lungs specifically and represents a noninvasive alternative for targeting genes to the lung ...
https://medicalxpress.com/news/2009-06-vaporized-viral-vector-anti-cancer-gene.html
Jun 08, 2009 · "Our results demonstrated that lentivirus-mediated CTMP overexpression suppressed Akt activity and inhibited tumor progression," wrote Dr. Cho. "Repeated aerosol gene delivery …
https://www.nature.com/articles/cgt20136
Feb 08, 2013 · Co-delivery of LETM1 and CTMP synergistically inhibits tumor growth in H-ras12V liver cancer model mice ... Repeated aerosol delivery of carboxyl …Author: Shin Jy, Chung Ys, Kang B, Jiang Hl, Yu Dy, Han K, Chae C, Moon Jh, Jang G, Cho Mh
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