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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215502/
Feb 07, 2010 · Drug Delivery Index (DDI) and Clinical Evaluation of Colon-Specific Drug Delivery Systems DDI is a calculated pharmacokinetic parameter, following single or multiple dose of oral colonic prodrugs. DDI is the relative ratio of RCE (Relative colonic tissue exposure to the drug) to RSC (Relative amount of drug in blood i.e. that is relative systemic exposal to the drug).Author: Anil K. Philip, Betty Philip
https://www.pharmatutor.org/articles/colon-targetted-drug-delivery-systems-review
Colon-specific drug delivery system is considered to be beneficial in the treatment of colonic diseases. The colon is a site where both local or systemic drug delivery could be achieved, topical treatment of inflammatory bowel disease, e.g. ulcerative colitis or Crohn’s disease.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508299/
Jun 13, 2015 · Polysaccharide-based delivery systems have several advantages and are therefore becoming a popular option for colon-specific delivery of drugs. Some of the advantages with polysaccharide use include availability, easy modifications, stability, safety, and biodegradability ( 4 ).Author: Seth Amidon, Jack E. Brown, Vivek S. Dave
https://www.japsonline.com/admin/php/uploads/363_pdf.pdf
Colon Specific Drug Delivery Systems: A Review on Various Pharmaceutical Approaches Prasanth V.V, Jayaprakash. R, Sam T. Mathew ABSTRACT Colon specific drug delivery system has attracted considerable attention for the past few years in order to develop drug delivery systems that are able to release drugs specifically in the
http://www.authorstream.com/Presentation/chinmayeechinni-1521280-colon-drug-delivery-system/
Aug 29, 2012 · Drug absorption in the colon. Hydrophilic drugs Lipophilic drugs Colon contents—More viscous with progressive absorption of water & delays the diffusion of drug from the lumen to mucosa. Colonic epithelial permeability modified by enhancers. Ex:-Ca+2 EDTA, Saponins,Bile salts, Fatty acids.
http://www.jpsbr.org/index_htm_files/5.pdf
the colon, as a site for drug delivery, offers distinct advantages on account of near neutral pH, a much longer transit time, relatively low proteolytic enzymatic activity and offers a much greater responsiveness to absorption enhances. Colon specific delivery systems should prevent the
http://www.thepharmajournal.com/vol1Issue7/Issue_sept_2012/3.3.pdf
Today, colon specific drug delivery is challenging task to pharmaceutical technologists. Therapeutic advantages of targeting drug to the diseased organ include. Therapeutic advantages of targeting drug to the diseased organ includes1,2 a) The ability to cut down the conventional dose b) Reduced the incidence of adverse site effects c) Delivery of drug in its intact form as close
https://www.researchgate.net/publication/244994822_Colon_targeted_drug_delivery_systems-A_review
Colonic drug delivery has gained increased importance not just for the delivery of the drugs for the treatment of local diseases associated with the colon like Crohn's disease, ulcerative colitis,...
https://www.slideshare.net/GajananSanap/colon-targeted-drug-delivery-systems
Feb 27, 2016 · As most of the conventional drug delivery systems for treating colon disorders such as inflammatory bowel diseases, infectious diseases and colon cancer are failing as the drugs don't reach the site of action in appropriate concentration. Thus an effective and safe therapy of these colonic disorders using site specific drug delivery system. The therapeutic advantages of targeting drug to the diseased organ include, a)Delivery of drug …
http://publications.waset.org/9996917/development-and-optimization-of-colon-targeted-drug-delivery-system-of-ayurvedic-churna-formulation-using-eudragit-l100-and-ethyl-cellulose-as-coating-material
The purpose of this study was to prepare time and pH dependent release tablets of Ayurvedic Churna formulation and evaluate their advantages as colon targeted drug delivery system. The Vidangadi Churna was selected for this study which contains Embelin and Gallic acid. Embelin is used in Helminthiasis as therapeutic agent.
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