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http://ijpsr.com/bft-article/advantageous-nasal-drug-delivery-system-a-review/?view=fulltext
Advantages of Nasal Drug Delivery System 1, 4: Drug degradation that is observed in the gastrointestinal tract is absent. Hepatic first – pass metabolism is absent. Rapid drug absorption and quick onset of action can be achieved. The bioavailability of larger drug molecules can be …
https://www.pharmatutor.org/articles/nasal-drug-delivery-system-complete-review
The purpose of this review, to provide a complete information about nasal drug delivery system such as advantage, limitations, anatomy of nose, mechanism of drug absorption, factors affecting of nasal drug delivery, absorption improvement aspects, novel drug formulations, types of nasal drug delivery system with uses of nasal drug delivery in ...
https://link.springer.com/article/10.1007%2Fs13346-012-0111-1
Nov 08, 2012 · Despite the obvious advantages of intranasal drug delivery, the nasal cavity presents a number of limitations for drug absorption, including low intrinsic permeability for some drugs, such as hydrophilic molecules, peptides, proteins, and nucleotides, rapid mucociliary clearance, and enzymatic degradation [ 1, 2 ].Author: Colin Diekens, Julia Kimbell, Jeffry Schroeter
https://www.thepharmaeducation.com/2020/04/Nasal-Drug-Delivery-System.html
The Pharma Education Network is an interactive platform has been created with the aim to provide information and support to the pharmacy students and pharmaceutical professionals.
https://www.ondrugdelivery.com/wp-content/uploads/2018/11/Nov2005.pdf
become the dominant delivery principle in nasal drug delivery. Direct-Haler is the first drug deliv-ery company to take advantage of this device-dependent reflex for enhancing nasal drug deliv-ery. Naturally, the increased interest in this princi-ple for enhanced nasal delivery has recently led other companies to seek exploitation of the same
https://www.slideshare.net/kawii/nasal-drug-delivery-system-41893460
Nov 22, 2014 · Medications absorbed across the olfactory mucosa directly enter the brain. This area is termed the nose brain pathway and offers a rapid, direct route for drug delivery to the brain. Olfactory mucosa Highly vascular nasal mucosa Brain CSF JNTUH,CPS,13031S0304 5. ADVANTAGES OF NASAL DRUG DELIVERY SYSTEM 1. A non invasiveroute.
https://pediatrics.aappublications.org/content/100/1/143
The advantages of relatively rapid absorption offered by this drug delivery system make it a reasonable alternative to intravenous therapy. Some have argued that narcotics administered to children should have a disagreeable taste, precluding the use of this oral transmucosal drug delivery system.
http://intranasal.net/Overview/default.htm
Therapeutic Intranasal Drug Delivery ... Delivery Method Advantages Disadvantages; Oral Painless Ease of use No shot needed Many medications available for this delivery method ... Even nasal drug delivery can have problems depending on the delivery method. Yuen et al report that in 5.3% of pediatric patients they were unable to dispense drops ...
https://www.ncbi.nlm.nih.gov/pubmed/15737247/
Despite problems with low lung deposition with all of the early devices, evidence accumulated that supported the advantages of the inhalation route over other drug-administration routes. Inhaled drugs are localized to the target organ, which generally allows for a lower dose than is necessary with systemic delivery (oral or injection), and thus fewer and less severe adverse effects.Author: Joseph L Rau
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