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https://www.researchgate.net/publication/43356074_Advances_in_cell-type_specific_delivery_of_RNAi-based_therapeutics
Request PDF Advances in cell-type specific delivery of RNAi-based therapeutics RNAi-based gene silencing mechanisms have emerged as indispensible tools for experimentally induced, sequence ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378126/
Mar 16, 2009 · RNAi-based therapeutics are currently being tested in various phase I and II clinical trials, however there are still several problems to overcome before their clinical application becomes widespread. Obtaining specific and effective delivery into the …Author: Katrin Tiemann, John J. Rossi
https://altogen.com/transfection-resource/rnai-therapeutics/
RNAi Therapeutics. RNAi Therapeutics refers to the use of RNAi technology to treat genetic diseases and certain disorders. By changing the protein expression in cells, some genetically-linked diseases can at least be temporarily cured; the proteins expressed by cells …
https://www.annualreviews.org/doi/full/10.1146/annurev-pharmtox-010715-103633
A resurgence in clinical trials using RNA interference (RNAi) occurred in 2012. Although there were initial difficulties in achieving efficacious results with RNAi without toxic side effects, advances in delivery and improved chemistry made this resurgence possible. More than 20 RNAi-based therapeutics are currently in clinical trials, and several of these are Phase III trials. Continued ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649006/
RNA interference (RNAi) is an evolutionarily conserved, endogenous process for post-transcriptional regulation of gene expression. Although RNAi therapeutics have recently progressed through the pipeline toward clinical trials, the application of these as ideal, clinical therapeutics requires the development of safe and effective delivery systems.Author: Jiehua Zhou, Ka To Shum, John C. Burnett, John J. Rossi
https://onlinelibrary.wiley.com/doi/10.1002/adtp.201800065
Recently, there have been several reviews focusing on RNA‐based therapeutics. 12, 13 In this review, we present the overview of RNA‐based therapeutics and recent advances including their delivery systems and clinical applications. In addition, the current challenges faced by RNA‐based drugs will be discussed and this will be followed by ...Author: Hojeong Shin, Se‐Jin Park, Yeajee Yim, Jungho Kim, Chulwon Choi, Cheolhee Won, Dal‐Hee Min
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(17)30099-0
RNAi-based therapy holds great promise, as it can be utilized for the treatment of multiple conditions in an accurate manner via sequence-specific manipulation of gene expression. To date, RNAi therapeutics have advanced into clinical trials for liver diseases and solid tumors; however, delivery of RNAi to leukocytes in general and to ...Author: Shoshy Mizrahy, Inbal Hazan-Halevy, Niels Dammes, Dalit Landesman-Milo, Dan Peer
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