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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053525/
Mucoadhesion is commonly defined as the adhesion between two materials, at least one of which is a mucosal surface. Over the past few decades, mucosal drug delivery has received a great deal of attention. Mucoadhesive dosage forms may be designed to enable ...
https://www.fda.gov/regulatory-information/search-fda-guidance-documents/assessing-adhesion-transdermal-delivery-systems-and-topical-patches-andas-draft-guidance-industry
GUIDANCE DOCUMENT. Assessing Adhesion with Transdermal Delivery Systems and Topical Patches for ANDAs Draft Guidance for Industry October 2018
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943741/
Dec 10, 2019 · A detailed application of GG in drug delivery applications has been extensively reported for several applications (Table 1), including oral drug delivery formulations based on GG, ophthalmic drug delivery formulations, nasal drug delivery formulations, and topical drug delivery formulations [74,89].Author: Thangavelu Muthukumar, Jeong Eun Song, Gilson Khang
https://www.sciencedirect.com/science/article/pii/S2352940718304529
This reduces drug delivery efficiency because insufficient adhesion of the carriers to the target results in rapid decrease of drug concentration and thus low sustainability . Therefore, generating microparticles with homogeneous size distribution and strong adhesion property is highly in demand for constructing efficient drug delivery systems.Author: Yuetong Wang, Yuetong Wang, Luoran Shang, Guopu Chen, Changmin Shao, Yuxiao Liu, Peihua Lu, Fei Rong...
https://www.sciencedirect.com/science/article/pii/S0168365919307254
Traditionally, medications, especially hormones, were most commonly orally used for IUAs preventions. Technological advances in therapeutic delivery systems have led to a broader choice for drug administration [, , , , , ].Local intrauterine delivery is often an ideal route since it could apply a lower dose and less frequency compared with the oral or intravenous administration [].Author: Longfa Kou, Xue Jiang, Shuyi Xiao, Ying-Zheng Zhao, Qing Yao, Ruijie Chen
https://www.fda.gov/media/98634/download
Assessing Adhesion With Transdermal and Topical Delivery Systems for ANDAs Guidance for Industry DRAFT GUIDANCE This guidance document is being distributed for comment purposes only.
https://www.nature.com/articles/s41598-020-62410-3
Mar 25, 2020 · In the third step, the effects of the blood flow velocity (both magnitude and the direction) and the vortex on the surface adhesion were investigated in the targeted delivery of drug-containing MBs.
https://www.researchgate.net/publication/317637304_Bioadhesive_drug_delivery_systems_Overview_and_recent_advances
This review provides an overview of the understanding of bioadhesive drug delivery system along with the recent advances in their formulation development. ... Adhesion may be defined sim ply as a ...Author: Devarshi Brahmbhatt
https://www.ondrugdelivery.com/design-validation-testing-drug-delivery-devices/
Citation: Turner M, “Design Validation Testing – Drug Delivery Devices”. ONdrugDelivery Magazine, Issue 79 (Oct 2017), pp 20-22. From a regulatory perspective, Mark Turner provides a summary of the current requirements of parenteral device manufacturers in the area of design validation testing.
https://www.dupont.com/content/dam/Dupont2.0/Products/healthcaresolutions/literature/52-1070C-01.pdf
and/or drug matrix. Every specific transdermal patch typically requires a number of properties that can be drug dependent like: n Good adhesion profile for the application period n Adequate drug loading n Manageable patch size n Sufficient skin flux of the drug n Sufficient control of the delivery rate to …
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