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https://www.nejm.org/doi/full/10.1056/NEJM199605023341809
Adenoviruses as Gene-Delivery Vehicles. James M. Wilson, M.D., Ph.D. This article has no abstract; the first 100 words appear below. For gene therapy to realize its clinical potential, there must be efficient and safe strategies of delivering therapeutic genes to somatic cells in vivo.Author: James M. Wilson
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900005/
Jan 01, 2014 · First, there is no question that the adenovirus is the most effective means of delivering genes in vivo. Most human cells express the coxsackie-adenovirus primary adenovirus receptor as well as the secondary integrin receptors (Sharma et al., 2009; Smith et al., 2010; Chen and Lee, 2013; Wolfrum and Greber, 2013 ),...Author: Ronald G. Crystal
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(04)01342-5
Oct 01, 2004 · Adenoviruses were initially vectored as vehicles for gene therapy. Attempts to replace missing or faulty genes by adenoviral gene transfer were largely unsuccessful in experimental animals and human volunteers alike due to innate and adaptive immune responses induced by the adenoviral …Author: Nia Tatsis, Hildegund C.J. Ertl
https://www.researchgate.net/publication/225264340_Adenovirus-Mediated_Gene_Delivery
Adenoviruses, which were first isolated in the 1950s, have been developed as gene-delivery vehicles, or vectors, since the early 1980s.
https://researchers.dellmed.utexas.edu/en/publications/pegylated-adenoviruses-for-gene-delivery-to-the-intestinal-epithe
PEGylation enhanced adenovirus transduction efficiency 10- to 40-fold in vivo in intestinal segments that do not express significant amounts of adenovirus receptors (jejunum, colon) with transgene expression located in the crypt regions. Conclusions. PEGylated adenoviruses are suitable gene delivery vehicles for oral administration.Author: Xuan Cheng, Xin Ming, Maria A. Croyle
https://www.sciencedirect.com/science/article/pii/S0958166910001187
Adenovirus: a blueprint for non-viral gene delivery. ... an understanding of the mechanisms of DNA delivery that adenoviruses use is of vital importance to the design of next-generation non-viral gene delivery systems. Adenoviruses overcome a series of biological barriers, including endosomal escape, intracellular trafficking, capsid ...Author: V Ann Chailertvanitkul, Colin W Pouton
https://www.intechopen.com/books/adenoviruses/adenoviral-vector-based-vaccines-and-gene-therapies-current-status-and-future-prospects
Initially, human adenoviruses, especially adenovirus 5 (HAd5), were developed as gene delivery vectors. Since the first generation of adenoviral vectors, based on E1 deletion, a number of different strategies have been employed to further improve the gene-carrying capacity and safety by deleting more genes.Author: Shakti Singh, Rakesh Kumar, Babita Agrawal
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1727540/
Although the gastrointestinal tract is a potentially attractive target for gene therapy approaches, only a few studies on the use of viral gene transfer vehicles in the gut have been reported. The prospects of using recombinant adenoviruses for gene delivery into epithelial and subepithelial cells of the normal and inflamed colon are here analysed.Author: S Wirtz, P R Galle, M F Neurath
https://en.wikipedia.org/wiki/Adenoviridae
Adenoviruses (members of the family Adenoviridae) are medium-sized (90–100 nm), nonenveloped (without an outer lipid bilayer) viruses with an icosahedral nucleocapsid containing a double stranded DNA genome. Their name derives from their initial isolation from human adenoids in 1953.. They have a broad range of vertebrate hosts; in humans, more than 50 distinct adenoviral serotypes have been ...Family: Adenoviridae
https://www.sciencedirect.com/topics/medicine-and-dentistry/human-adenovirus-c
Because HAdV vector effectively transduces cells, it has been widely used as gene delivery vectors of transgenes in the research fields of gene therapy and basic science. Therefore, HAdV vector is a feasible vehicle to deliver noncoding ribonucleic acids (ncRNAs) in mammalian cells.
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