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https://www.researchgate.net/publication/234135100_Acid-degradable_polymers_for_drug_delivery_A_decade_of_innovation
Acid-degradable polymers for drug delivery: A decade of innovation Article (PDF Available) in Chemical Communications 49(21) · January 2013 with 1,627 Reads How we measure 'reads'
https://www.ncbi.nlm.nih.gov/pubmed/23320254
Mar 14, 2013 · Acid-degradable polymers for drug delivery: a decade of innovation. ... The advances in the design of acid-degradable polymers and drug delivery systems have been summarized and discussed in this review article. Various acid-labile groups such as acetals, orthoester, hydrazones, imines and cis-aconityl, that can undergo cleavage in slightly ...Author: Sandra Binauld, Martina H. Stenzel
https://pubs.rsc.org/en/content/articlelanding/2013/cc/c2cc36589h
Polymers that start degrading under acidic conditions are increasingly investigated as a pathway to trigger the release of drugs once the drug carrier reached the slightly acidic tumour environment or after the drug carrier has been taken up by cells, resulting in the localization of the polymer in the acidic endosomes and lysosomes. The advances in the design of acid-degradable polymers and ...Author: Sandra Binauld, Martina H. Stenzel
https://www.researchgate.net/profile/Martina_Stenzel/publication/234135100_Acid-degradable_polymers_for_drug_delivery_A_decade_of_innovation/links/00b7d52129aa952d91000000/Acid-degradable-polymers-for-drug-delivery-A-decade-of-innovation.pdf
Acid-degradable polymers for drug delivery: a decade of innovation Sandra Binauld and Martina H. Stenzel* Polymers that start degrading under acidic conditions are increasingly investigated as a ...
https://pubs.acs.org/doi/abs/10.1021/ma201085z
Design and development of polymeric micelles with cleavable links for intracellular drug delivery. Progress in Polymer Science 2013, 38 (3-4) , 503-535. DOI: 10.1016/j.progpolymsci.2012.07.002. Sandra Binauld, Martina H. Stenzel. Acid-degradable polymers for drug delivery: a decade of innovation.Author: Hien Thi Thu Duong, Christopher P Marquis, Michael Raymond Whittaker, Thomas Paul Davis, Cyrille Boy...
https://pubs.acs.org/doi/10.1021/bm061234z
In this communication we demonstrate that acyclic diene metathesis (ADMET) polymerization is a powerful methodology for the synthesis of acid-degradable polymers based on polyketals and polyacetals. Ten new polyketals and polyacetals were synthesized, using ADMET, and a polyacetal based on anthracene aldehyde was identified, which had the physical properties needed for …Author: Sirajud D. Khaja, Sungmun Lee, Niren Murthy
http://www.chemistry.unsw.edu.au/research/research-groups/stenzel-group/publications
Recent publications. Enhanced Delivery of the RAPTA-C Macromolecular Chemotherapeutic by Conjugation to Degradable Polymeric M icelles . ... Acid-degradable polymers for drug delivery: a decade of innovation. ... Old chemistry rediscovered to connect polymers with nature’s building blocks.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603510/
Oct 06, 2015 · Increased brain uptake of targeted nanoparticles by adding an acid-cleavable linkage between transferrin and the nanoparticle core ... Mechanisms of TfR-mediated transcytosis and sorting in epithelial cells and applications toward drug delivery. Adv Drug Deliv ... Binauld S, Stenzel MH. Acid-degradable polymers for drug delivery: A decade of ...Author: Andrew J. Clark, Mark E. Davis
https://www.sciencedirect.com/science/article/pii/S0168365919303438
siRNA holds tremendous promise to knockdown the disease-promoting gene in any cell type that it can be delivered. The biggest challenge facing the clinical translation of siRNA is to overcome the barriers that impede the in vivo delivery. siRNA is a highly hydrophilic macromolecule with poor pharmacological properties. The critical requirement for broadening the systemic siRNA delivery is to ...Author: Wanyi Tai, Wanyi Tai
https://www.sciencedirect.com/science/article/pii/S1319016420300050
In this review, it was focused on the most recent advances in the development of stimuli-responsive nanocarriers for drug delivery in cancer therapy. These smart drug delivery systems respond to the distinct changes in cancer cells, such as changes in pH gradient and elevated secretion of certain enzymes, rather than the conditions in normal cells.Author: Mosa Alsehli
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