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http://dmd.aspetjournals.org/content/42/11/1881
Nov 01, 2014 · Subcutaneous absorption of biotherapeutics is relatively slow and mostly incomplete. Knowledge of the subcutaneous tissue is important to understand the absorption kinetics after subcutaneous administration. Transport in the subcutis to the absorbing blood or lymph capillaries appears to be a major contributor to the slow subcutaneous absorption.
https://www.sciencedirect.com/science/article/pii/S0168365903004632
Furthermore, some agents have been shown to be relatively non-toxic even when used at high concentrations. The objective of this report is to provide an overview of the mechanisms of action, efficacy, and toxicity of some of the various agents utilized as absorption enhancers in …Author: Alamdar Hussain, John J. Arnold, Mansoor A. Khan, Fakhrul Ahsan
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/protein-absorption
Gaurang Patel, Ambikanandan Misra, in Challenges in Delivery of Therapeutic Genomics and Proteomics, 2011. Publisher Summary. This chapter discusses in detail the factors affecting protein and peptide absorption, barriers to protein absorption, penetration pathways, and various approaches to improve the oral delivery of proteins and peptides.The chapter also elaborates the methods to study ...
http://www.ijpsonline.com/articles/protein-and-peptide-drug-delivery-oral-approaches.pdf
delivery. These advantages are particularly relevant for the treatment of pediatric patients and include the avoidance of pain and discomfort associated with injections and the elimination of possible infections *For correspondence E-mail: [email protected] RReview eview AArticlerticle Protein and Peptide Drug Delivery: Oral ApproachesAuthor: Jessy Shaji, V Patole
https://www.researchgate.net/publication/323317941_Buccal_Delivery_of_Peptides_and_Proteins
Buccal route is a natural route and it has been used for delivery of small molecule for many years, but only during the last decade, delivery of macromolecules via buccal mucosa has attracted ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595342/
This finding has led to the concept that there is a maximal anabolic response to protein intake with a meal, and that the normal amount of protein eaten with dinner will generally exceed the maximally-effective intake of protein. However, protein breakdown has not been taken into account when evaluating the anabolic response to protein intake.Author: Nicolaas Ep Deutz, Robert R Wolfe
https://en.wikipedia.org/wiki/Protein_adsorption
Both oxidation and corrosion will lower the free energy, thus affecting protein adsorption as seen in Eq. 1. Effects of Topography. Surface roughness and texture has an undeniable influence on protein adsorption on all materials, but with the ubiquity of metal machining processes, it is useful to address how these impact protein behavior.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512569/
Jul 23, 2015 · Introduction. Intensive insulin management and good glycaemic control are essential for the prevention of acute and long-term diabetes complications and the overall wellbeing in people with type 1 diabetes [1, 2].Multiple daily injection (MDI) therapy involves injecting long-acting insulin once or twice daily (basal) and injections of rapid-acting insulin before each meal.Author: Megan Paterson, Megan Paterson, Kirstine J. Bell, Susan M. O’Connell, Carmel E. Smart, Carmel E. Sma...
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