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https://www.nature.com/articles/nbt.2634
Jul 09, 2013 · A window onto siRNA delivery. Yuhua Wang 1 & ... Peptide‐Targeted, Fusogenic Porous Silicon Nanoparticles for Delivery of siRNA Byungji Kim, Si Sun, Judith A. Varner , Stephen B ...Author: Yuhua Wang, Leaf Huang
https://www.ncbi.nlm.nih.gov/pubmed/23839146
1. Nat Biotechnol. 2013 Jul;31(7):611-2. doi: 10.1038/nbt.2634. A window onto siRNA delivery. Wang Y, Huang L. Comment on Nat Biotechnol. 2013 Jul;31(7):638-46.Author: Yuhua Wang, Leaf Huang
https://www.researchgate.net/publication/248384464_A_window_onto_siRNA_delivery
The greatest challenge standing in the way of effective in vivo siRNA delivery is creating a delivery vehicle that mediates a high degree of efficacy with a broad therapeutic window.
https://www.deepdyve.com/lp/nature-publishing-group-npg/a-window-onto-sirna-delivery-145ENrmCmO
Jul 09, 2013 · A window onto siRNA delivery Perhaps the most serious obstacle to siRNA drug development is delivery, as only a tiny fraction of an injected dose arrives safely in the cytosol of target cells. Improving delivery efficiency will likely require greater insight into the mechanisms by which cells take up siRNA.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054481/
Aug 10, 2018 · NPSCs are an effective platform for spleen-directed siRNA delivery and immunomodulation in vivo. The direct cytosolic delivery of siRNA, coupled with the splenic directed ability, contributes to potent RNAi in vivo, enabling silencing of proinflammatory cytokines with a total siRNA dose as low as 0.56 mg/kg.Author: Ying Jiang, Joseph Hardie, Yuanchang Liu, Moumita Ray, Xiang Luo, Xiang Luo, Riddha Das, Ryan F. Lan...
https://europepmc.org/articles/PMC3814166
Jun 23, 2013 · Our data suggests that siRNA delivery efficiency might be improved by designing delivery vehicles that can escape the recycling pathways. Small interfering RNAs (siRNA) are a potential new class of medicines that can selectively silence disease-causing genes 1 – 3 .Author: Gaurav Sahay, William Querbes, Christopher Alabi, Ahmed Eltoukhy, Sovan Sarkar, Christopher Zurenko,...
https://www.nature.com/articles/nbt.2614
Jun 23, 2013 · Detailed analyses of siRNA delivery by lipid nanoparticles reveal major pathways of siRNA internalization and endosomal escape. Despite efforts to …Author: Gaurav Sahay, William Querbes, Christopher Alabi, Ahmed Eltoukhy, Sovan Sarkar, Christopher Zurenko,...
https://www.nature.com/articles/nbt.2612
Jun 23, 2013 · Delivery of short interfering RNAs (siRNAs) remains a key challenge in the development of RNA interference (RNAi) therapeutics. A better understanding of the mechanisms of siRNA cellular uptake, intracellular transport and endosomal release could critically contribute to the improvement of delivery methods.
https://www.sciencedirect.com/science/article/pii/S1773224717307025
In conclusion, mNPs carrying siRNA, or dsDNA were capable of delivering the payload from nose to brain. This approach for delivery of gene therapies to humans, if successful, will have a significant impact on disease-modifying therapeutics of neurodegenerative diseases.Author: Juan Sanchez-Ramos, Shijie Song, Xiaoyuan Kong, Parastou Foroutan, Gary Martinez, William Dominguez-...
https://www.researchgate.net/publication/325592056_Nanocapsule-mediated_cytosolic_siRNA_delivery_for_anti-inflammatory_treatment
Specifically, we discuss the main approaches developed so far to load siRNA into/onto NPs, and NP surface chemistry engineered for enhanced intracellular siRNA delivery, endosomal escape, and ...
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