A Regulated Delivery System For Inner Ear Drug Application

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A regulated delivery system for inner ear drug application ...

    https://www.sciencedirect.com/science/article/pii/S0168365913000047
    This important modification to our drug delivery system has the ability to deliver therapy to the inner ear until desired effect is achieved and to stop this process when side effects or treatment-related ototoxicities start to occur, providing a novel and salient approach for safe and effective delivery to …Author: Shayanne A. Lajud, Zhao Han, Fang-Lu Chi, Rende Gu, Danish A. Nagda, Orysia Bezpalko, Samudra Sanyal...

A Novel Regulated Nanohydrogel Delivery System for ...

    https://grantome.com/grant/NIH/R01-DC014464-03
    In this proposal, the PI hypotheizes that the use of a regulated CGP-hydrogel-MNFP system (nanohydrogel) would result in a controlled, targeted, and highly effective delivery platform, bringing therapeutic biomaterial agents to specific cellular structures within the inner ear for the treatment of inner ear diseases This unique system has the ...

Current strategies for drug delivery to the inner ear ...

    https://www.sciencedirect.com/science/article/pii/S2211383513000178
    For many years, drug delivery to the inner ear has been a challenge to physicians in the treatment of inner ear disorders. In the past decade, the field of inner ear drug delivery has emerged with the development of new biomaterials and drug delivery technologies to improve the effectiveness of …Author: Hongzhuo Liu, Hongzhuo Liu, Jinsong Hao, Kevin S. Li

Novel in vivo imaging analysis of an inner ear drug ...

    https://keio.pure.elsevier.com/en/publications/novel-in-vivo-imaging-analysis-of-an-inner-ear-drug-delivery-syst-2
    Dec 01, 2015 · Systemic application of drugs is commonly used in clinical situations. Some of these drugs are ototoxic. Since there are few studies on in vivo monitoring of drug delivery dynamics, the time course or bioavailability of drugs in the inner ear of live animals following systemic drug application remains unknown.Author: Sho Kanzaki, Kotaro Watanabe, Masato Fujioka, Shinsuke Shibata, Masaya Nakamura, Hirotaka James Okan...

(PDF) Regulated Chitosan-Based Inner-Ear Drug Delivery

    https://www.researchgate.net/publication/272385050_Regulated_Chitosan-Based_Inner-Ear_Drug_Delivery
    Regulated Chitosan-Based Inner-Ear Drug Delivery. ... This system has a potential to stop inner ear drug application when side effects or drug-related toxicities start to occur and should be used ...

Principles of Local Drug Delivery to the Inner Ear

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820328/
    Nov 16, 2009 · Pharmacokinetics of the Inner Ear. Although the ‘LADME’ scheme was developed to describe the pharmacokinetic processes in the human body following a given dosage regimen, it is helpful to adopt this concept for understanding and investigating the principles of drug movements in the inner ear after local or systemic application.Author: Alec N. Salt, Stefan K. Plontke

Regulated Chitosan-Based Inner-Ear Drug Delivery ...

    https://journals.sagepub.com/doi/abs/10.1177/0194599812451438a175
    Conclusion: Our study suggests that the chitosanase-based regulation system can be effectively used for controlled inner ear drug delivery. This system has a potential to stop inner ear drug application when side effects or drug-related toxicities start to occur and should be …Author: Shayanne A. Lajud, Zhao Han, Andres Bur, Samudra Sanyal, Orysia Bezpalko, Bert W. O’Malley, Daqing L...

Novel in vivo imaging analysis of an inner ear drug ...

    https://www.ncbi.nlm.nih.gov/pubmed/26435094
    Since there are few studies on in vivo monitoring of drug delivery dynamics, the time course or bioavailability of drugs in the inner ear of live animals following systemic drug application remains unknown. For instance, it is unknown whether the volume of a drug delivered systemically correlates with its inner ear pharmacokinetics.Author: Sho Kanzaki, Kotaro Watanabe, Masato Fujioka, Shinsuke Shibata, Masaya Nakamura, Hirotaka James Okan...

Dr. Andres Bur, ENT-Otolaryngologist in Kansas City, KS ...

    https://health.usnews.com/doctors/andres-bur-1011746
    A regulated delivery system for inner ear drug application. Lajud SA, Han Z, Chi FL, Gu R, Nagda DA, Bezpalko O, Sanyal S, Bur A, Han Z, O'Malley BW Jr, Li D The design and characterization of a ...

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