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https://www.ncbi.nlm.nih.gov/pubmed/7562407
In this paper, we evaluate the roles played by various ultrasound-related phenomena, including cavitation, thermal effects, generation of convective velocities, and mechanical effects, in the ultrasonic enhancement of transdermal drug delivery (sonophoresis).Author: Samir Mitragotri, David A. Edwards, David A. Edwards, Daniel Blankschtein, Robert Langer
https://onlinelibrary.wiley.com/doi/abs/10.1002/jps.2600840607
A mechanistic study of ultrasonically‐enhanced transdermal drug delivery Samir Mitragotri Department of Chemical Engineering, Massachusetts Institute of Technology…Author: Samir Mitragotri, David A. Edwards, David A. Edwards, Daniel Blankschtein, Robert Langer
https://www.sciencedirect.com/science/article/abs/pii/S0022354915498168
Although ultrasound has been shown to enhance the transdermal transport of a variety of drugs, the mechanisms underlying this phenomenon are not clearly understood.Author: Samir Mitragotri, David A. Edwards, David A. Edwards, Daniel Blankschtein, Robert Langer
https://onlinelibrary.wiley.com/doi/pdf/10.1002/jps.2600840607
Transdermal drug delivery offers several advantages over traditional drug delivery methods such as oral delivery and injection. Specifically, transdermal drug delivery (2) avoids the passage of drugs through the stomach and the intestine, (ii) offers better patient compliance, and (iii) provides sus- tained release of drugs over a sufficiently long time (up to a week). Transdermal drug delivery, however, …Author: Samir Mitragotri, David A. Edwards, David A. Edwards, Daniel Blankschtein, Robert Langer
https://drugdelivery.seas.harvard.edu/publications/mechanistic-study-ultrasonically-enhanced-transdermal-drug-delivery
“A Mechanistic Study of Ultrasonically-Enhanced Transdermal Drug Delivery.” J. Pharm. Sci., 84, 84, Pp. 697-706. A Mechanistic Study of Ultrasonically-Enhanced Transdermal Drug Delivery The Mitragotri Laboratory for Drug Delivery
https://asa.scitation.org/doi/full/10.1121/1.422081
The transdermal route of drug delivery offers a noninvasive and painless alternative to more traditional routes such as injections. However, its applicability is limited to only a handful of drugs due to the low permeability of the skin. It has been demonstrated that low‐frequency ultrasound significantly enhances transdermal transport of a variety of drugs (sonophoresis).Author: J. M. Farrell, S. Mitragotri, S. Theis, J. Kost, R. Langer
https://www.academia.edu/13558735/A_mechanistic_study_of_ultrasonically-enhanced_transdermal_drug_delivery
A mechanistic study of ultrasonically-enhanced transdermal drug delivery
https://www.nature.com/articles/nrd1304
Feb 01, 2004 · The limitations of transdermal drug delivery are governed largely by skin anatomy ( Fig. 1 ). As the largest organ of the human body, skin provides a painless and compliant interface for systemic drug administration 9. However, skin has evolved to impede the flux of toxins into the body and minimize water loss,...Author: Mark R. Prausnitz, Samir Mitragotri, Robert Langer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436072/
Jun 30, 2011 · Chemical enhancers, such as surfactants, are known to increase the rate of transdermal drug delivery by: i) increasing the stratum corneum lipid fluidity, ii) changing lipid organization,[ 116] iii) decreasing the path length and tortuosity across the stratum corneum, iv) increasing the skin diffusion coefficient,...Author: Baris E. Polat, Douglas Hart, Robert Langer, Daniel Blankschtein
https://www.sciencedirect.com/science/article/pii/S0022354915508873
Minireview Transdermal penetration enhancers: Applications, limitations, and potential Barrie C. Finnin, * [email protected] Timothy M. Morgan, Department of Pharmaceutics, Victorian College of Pharmacy, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia. Department of Pharmaceutics, Victorian College of Pharmacy, Monash University 381 Royal Parade Parkville Victoria 3052 ...Author: Barrie C. Finnin, Timothy M. Morgan
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