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http://onlinelibrary.wiley.com/doi/10.1002/anie.201209804/abstract
Apr 03, 2013 · Covering all three bases: Drug-delivery vehicles that encapsulate doxorubicin (Dox) within a pH-sensitive matrix embedded with gold nanoparticles were synthesized with Herceptin–poly(ethylene glycol) conjugates on the surface for the specific binding of cancer cells (see picture; NIR=near infrared). Cell targeting was combined with enhanced cytotoxicity through triggered drug release (at pH 5–6) and thermal ablation (a photothermal effect).
https://www.onlinelibrary.wiley.com/doi/full/10.1002/anie.201209804
Mar 11, 2013 · Covering all three bases: Drug‐delivery vehicles that encapsulate doxorubicin (Dox) within a pH‐sensitive matrix embedded with gold nanoparticles were synthesized with Herceptin–poly(ethylene glycol) conjugates on the surface for the specific binding of cancer cells (see picture; NIR=near infrared). Cell targeting was combined with enhanced cytotoxicity through triggered drug release (at pH 5–6) and thermal ablation (a photothermal effect).Author: Jin‐Oh You, Jin‐Oh You, Peng Guo, Debra T. Auguste
https://www.onlinelibrary.wiley.com/doi/abs/10.1002/anie.201209804
Covering all three bases: Drug‐delivery vehicles that encapsulate doxorubicin (Dox) within a pH‐sensitive matrix embedded with gold nanoparticles were synthesized with Herceptin–poly(ethylene glycol) conjugates on the surface for the specific binding of cancer cells (see picture; NIR=near infrared). Cell targeting was combined with enhanced cytotoxicity through triggered drug release (at pH 5–6) and thermal ablation (a photothermal effect).Author: Jin‐Oh You, Jin‐Oh You, Peng Guo, Debra T. Auguste
https://onlinelibrary.wiley.com/doi/10.1002/ange.201209804
A Drug‐Delivery Vehicle Combining the Targeting and Thermal Ablation of HER2+ Breast‐Cancer Cells with Triggered Drug Release†Author: Jin‐Oh You, Jin‐Oh You, Peng Guo, Debra T. Auguste
https://www.researchgate.net/publication/236049283_A_Drug-Delivery_Vehicle_Combining_the_Targeting_and_Thermal_Ablation_of_HER2_Breast-Cancer_Cells_with_Triggered_Drug_Release
A Drug-Delivery Vehicle Combining the Targeting and Thermal Ablation of HER2+ Breast-Cancer Cells with Triggered Drug Release Article in Angewandte Chemie International Edition 52(15) · April ...
https://www.augustelab.org/
A drug-delivery vehicle combining the targeting and thermal ablation of HER2+ breast-cancer cells with triggered drug release. Angew Chem Int Ed Engl. 2013 Apr 8;52(15):4141–6. Gunawan R, Almeda D, Auguste DT , “Complementary targeting of liposome to IL-1α and TNF-α activated endothelial cells via the transient expression of VCAM1 and E ...
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/drug-delivery-vehicle
The size of the drug delivery vehicle is an important passive targeting parameter. Injectable circulating drug carriers must avoid uptake by the reticuloendothelial system (RES) to have a greater chance of reaching the target site. Reduced macrophage uptake is seen with nanoparticles that have hydrophilic surfaces,...
https://www.fusfoundation.org/mechanisms-of-action/drug-delivery-vehicles
Drug Delivery Vehicles Focused ultrasound can be used to release encapsulated drugs (e.g. genes, chemotherapeutics), delivering them in high concentrations to a …
“A drug-delivery vehicle combining the targeting and thermal ablation of HER2+ breast-cancer cells with triggered drug release,” Jin-Oh You, Peng Guo, and Debra T. Auguste, Angewandte Chemie-International Edition, 2013, 52(15) 4141-4146.
https://www.nature.com/articles/s41392-017-0004-3
Mar 16, 2018 · Moreover, they can also be used for 3D cell culture and as drug delivery vehicles 108,109. Hydrogels are efficient candidates for controlled release, bioadhesive and/or targeted drug delivery as they can encapsulate biomacromolecules, including proteins and DNA, and hydrophilic or hydrophobic drugs 110.Author: Sudipta Senapati, Arun Kumar Mahanta, Sunil Kumar, Pralay Maiti
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